Synthesis of pyrrolidinedione-fused hexahydropyrrolo[2,1-]isoquinolines via three-component [3 + 2] cycloaddition followed by one-pot -allylation and intramolecular Heck reactions.

Two kinds of [3 + 2] cycloaddition intermediates generated from the three-component reactions of 2-bromobenzaldehydes and maleimides with amino esters or amino acids were used for a one-pot -allylation and intramolecular Heck reactions to form pyrrolidinedione-fused hexahydropyrrolo[2,1-]isoquinolines. The multicomponent reaction was combined with one-pot reactions to make a synthetic method with good pot, atom and step economy. MeCN was used as a preferable green solvent for the reactions.