Publications by authors named "Suzanne van de Laar"
Purpose: Primary open-angle glaucoma (POAG) has been reported to occur more frequently in Africans, and to follow a more severe course compared to Europeans. We aimed to describe characteristics of POAG presentation and treatment across three ethnic groups from Africa and one from Europe.
Methods: We ascertained 151 POAG patients from South African Coloured (SAC) and 94 South African Black (SAB) ethnicity from a university hospital in South Africa.
Purpose: To assess the clinical and laboratory manifestations and vaccination status of uveitis patients positive for rubella virus (RV) in aqueous humor and investigate its relationship to Fuchs uveitis syndrome (FUS).
Methods: Retrospective study of all uveitis patients, positive for RV in aqueous humor analysis (polymerase chain reaction [PCR] and/or Goldmann-Witmer coefficient [GWC]) between January 2010 and October 2016 at the ophthalmology departments in the Erasmus Medical Center (Rotterdam) and University Medical Center Utrecht. Outcomes of aqueous analyses of FUS patients during this period were assessed.
Article Synopsis
- Primary open angle glaucoma (POAG) has a significant genetic component and shows varying prevalence among ethnic groups, being notably more common in black African populations.
- A genome-wide association study involving Tanzanian, South African, and African American samples identified a confirmed association with the TXNRD2 gene and revealed a genetic risk score linked to 15 previously known POAG loci.
- Additionally, a novel genetic locus associated with POAG was identified (EXOC4), but efforts to validate this finding in West African populations faced challenges due to genetic diversity, indicating the need for larger studies to better understand POAG in these groups.