Glomerulopathy in adult recipients of pediatric kidneys.

To compare "for cause" renal biopsies (bx) from adult recipients of pediatric-donor kidneys (PDK) versus adult-donor kidneys (ADKs), we reviewed 103 graft bx from 50 PDK recipients and 85 bx from 49 ADK recipients. PDK bx displayed more frequent glomerular pathology with immune complex-mediated glomerulonephritis present in 11/103 PDK versus 1/85 ADK (p < 0.05).

Graft-versus-host disease: case report and review of literature.

We describe a young patient with acute myeloid leukemia who, having been treated with allogenic hematopoietic stem cell transplantation, presented with acute graft-versus-host disease. One year later, leukemia relapse was treated with donor lymphocyte infusion and was followed by a new episode of acute graft-versus-host disease. The patient died 18 months after the transplantation, with evidence of chronic graft-versus-host disease in multiple organs.

Abundance of interstitial eosinophils in renal allografts is associated with vascular rejection.

Background: The authors investigated the possible relevance of significant interstitial graft eosinophilic infiltrate (SIGEI) to the pathologic diagnosis of renal transplants.

Methods: The authors performed a clinical and pathologic review of 29 consecutive patients with renal allograft failure and nephrectomy. As a result of their size, such specimens are more conducive than biopsies to the investigation of large blood vessels.

Diagnosis of congenital nephrotic syndrome: a clinical and a pathologic challenge.

The diagnosis of congenital nephrotic syndrome (NS) is a challenge both for clinicians and for pathologists. We observed three cases in a series of 50 children with NS nonresponsive to therapy, corresponding to one case each of minimal change disease, Finnish-type glomerulopathy, and diffuse mesangial sclerosis--two histopathologic studies were performed in each case. The age at presentation did not predict the diagnosis nor the prognosis: The NS presented at 7 months of age in the patient with diffuse mesangial sclerosis, but it was present at birth in the patient with minimal change disease.

Nephrotic syndrome and interstitial nephritis associated with celecoxib.

Nonsteroidal anti-inflammatory drugs (NSAIDs) are well known to cause fluid and electrolyte abnormalities and renal failure. NSAIDs also may cause an acute allergic interstitial nephritis (AIN) and the nephrotic syndrome, characterized by histologic pathology consistent with minimal change disease in patients with previously normal renal function. The nephrotoxic potential of cyclooxygenase 2 (COX-2) inhibitors has not been established because AIN associated with nephrotic syndrome has not been reported secondary to the COX-2 inhibitors.

Changes in cardiovascular responsiveness and cardiotoxicity elicited during binge administration of Ecstasy.

The recreational use of 3,4-methylenedioxymethamphetamine (MDMA; Ecstasy) is often characterized by a repeated pattern of frequent drug administrations (binge) followed by a period of abstinence. Radiotelemetry was used to characterize the cardiovascular responses elicited during three MDMA binges (3 or 9 mg/kg b.i.

Cardiovascular responses elicited by the "binge" administration of methamphetamine.

Methamphetamine (METH) abuse is often characterized by a repeated pattern of frequent drug administrations (binge) followed by a period of abstinence. The effect of this pattern of METH use on cardiovascular function has not been characterized. Radiotelemetry was used to record the cardiovascular responses elicited during three successive METH binges (3 mg/kg, b.