Publications by authors named "Suzanne M Silvis"
Importance: Efficient care processes are crucial to minimize treatment delays and improve outcome after endovascular thrombectomy (EVT) in patients with ischemic stroke. A potential means to improve care processes is performance feedback.
Objective: To evaluate the effect of performance feedback to hospitals on treatment times for EVT.
Article Synopsis
- A significant portion of patients (1 in 10) experience epilepsy after having cerebral venous thrombosis (CVT), but it's challenging to predict who will be affected.* -
- Researchers created the DIAS3 prognostic score using clinical data from over 1,100 patients to assess the likelihood of developing post-CVT epilepsy based on six clinical variables.* -
- The study found a range of predicted risks for post-CVT epilepsy within one and three years, with successful validation of the score confirming its effectiveness in estimating individual risk.*
Article Synopsis
- A new prognostic score, SI NCAL C, was created to estimate the risk of dependency and death in patients after cerebral venous thrombosis (CVT), aiding in future targeted therapies.
- The study used data from the International CVT Consortium, excluding patients with prior functional dependency, and employed logistic and Cox regression analyses to identify risk factors for poor outcomes.
- Results showed the score has good predictive accuracy (C-statistics around 0.80-0.84), but further external validation is needed to confirm its effectiveness before widespread use.
Article Synopsis
- The study investigates the prevalence and characteristics of dural arteriovenous fistulas (dAVFs) in patients with cerebral venous thrombosis (CVT), finding that 2.4% of CVT patients had dAVFs.
- It highlights that patients with dAVFs tend to be older, predominantly male, and more likely to experience chronic CVT onset, with specific imaging findings.
- Despite these associations, the clinical outcomes for patients with and without dAVFs were similar, with most fistulas identified either at the time of CVT diagnosis or afterward.
Background And Purpose: Cerebral venous sinus thrombosis (CVST) has been described after vaccination against SARS-CoV-2. The clinical characteristics of 213 post-vaccination CVST cases notified to the European Medicines Agency are reported.
Methods: Data on adverse drug reactions after SARS-CoV-2 vaccination notified until 8 April 2021 under the Medical Dictionary for Regulatory Activities Term 'Central nervous system vascular disorders' were obtained from the EudraVigilance database.
Article Synopsis
- A study examined late seizures (LS) after cerebral venous thrombosis (CVT) using data from 1,127 patients, focusing on their occurrence, characteristics, treatment, and predictors.
- About 11% of patients experienced LS during a median follow-up of 2 years, with the first seizure usually happening around 5 months post-CVT diagnosis.
- Key predictors for developing LS included having status epilepticus during the acute phase, undergoing decompressive hemicraniectomy, and experiencing acute seizures, highlighting a significant risk for recurrence which suggests the need for a proper epilepsy diagnosis.
Objective: To identify characteristics, predictors, and outcomes of acute symptomatic seizures (ASS) in cerebral venous thrombosis (CVT), we investigated 1,281 consecutive adult patients with CVT included from 12 hospitals within the International CVT Consortium.
Methods: We defined ASS as any seizure between symptom onset and 7 days after diagnosis of CVT. We stratified ASS into prediagnosis and solely postdiagnosis ASS.
Background and Purpose- Pregnancy and the postpartum period are generally considered to be risk factors for cerebral venous thrombosis (CVT), but no controlled studies have quantified the risk. Methods- Case-control study using data of consecutive adult patients with CVT from 5 academic hospitals and controls from the Dutch MEGA study (Multiple Environmental and Genetic Assessment of risk factors for venous thrombosis). Men, women over the age of 50, women using oral contraceptives or with a recent abortion or miscarriage were excluded.
View Article and Find Full Text PDFBackground And Purpose: Cerebral venous thrombosis (CVT) is rare in older patients. We investigated whether clinical features and outcomes differ in older and younger patients.
Methods: We used data from a multicenter observational registry of consecutive adult patients with CVT admitted between 1987 and 2016.
Cerebral venous thrombosis (CVT) is an important cause of stroke in young adults. Data from large international registries published in the past two decades have greatly improved our knowledge about the epidemiology, clinical manifestations and prognosis of CVT. The presentation of symptoms is highly variable in this disease, and can range from a patient seen at the clinic with a 1-month history of headache, to a comatose patient admitted to the emergency room.
View Article and Find Full Text PDFCerebral venous thrombosis (CVT) is a rare thrombotic disorder involving the cerebral veins and dural sinuses. In contrast to more common sites of venous thromboembolism (VTE), such as the legs and lungs, CVT mainly affects young adults and children, and women are affected three times more often than men. Although presenting symptoms are variable, headache is usually the first symptom, often in combination with focal neurologic deficits and epileptic seizures.
View Article and Find Full Text PDFImportance: Obesity is a risk factor for deep vein thrombosis of the leg and pulmonary embolism. To date, however, whether obesity is associated with adult cerebral venous thrombosis (CVT) has not been assessed.
Objective: To assess whether obesity is a risk factor for CVT.
Background And Purpose: Admission hyperglycemia is associated with poor clinical outcome in ischemic and hemorrhagic stroke. Admission hyperglycemia has not been investigated in patients with cerebral venous thrombosis.
Methods: Consecutive adult patients with cerebral venous thrombosis were included at the Academic Medical Center, The Netherlands (2000-2014) and the Helsinki University Central Hospital, Finland (1998-2014).