Publications by authors named "Suzanne Lockyer"
Article Synopsis
- The study investigates the effectiveness and cost-efficiency of two surgical approaches (vein bypass-first vs. best endovascular treatment-first) for treating chronic limb-threatening ischemia, which can lead to pain and tissue loss.
- Conducted in 40 medical centers across the UK, Sweden, and Denmark, the trial involved patients requiring revascularization due to atherosclerotic peripheral arterial disease.
- Key outcomes measured included amputation-free survival, overall survival rates, major amputations, quality of life, and costs associated with hospital treatments over a follow-up period of at least 2 years.
Background: Chronic limb-threatening ischaemia is the severest manifestation of peripheral arterial disease and presents with ischaemic pain at rest or tissue loss (ulceration, gangrene, or both), or both. We compared the effectiveness of a vein bypass first with a best endovascular treatment first revascularisation strategy in terms of preventing major amputation and death in patients with chronic limb threatening ischaemia who required an infra-popliteal, with or without an additional more proximal infra-inguinal, revascularisation procedure to restore limb perfusion.
Methods: Bypass versus Angioplasty for Severe Ischaemia of the Leg (BASIL)-2 was an open-label, pragmatic, multicentre, phase 3, randomised trial done at 41 vascular surgery units in the UK (n=39), Sweden (n=1), and Denmark (n=1).
Background: Spin in the reporting of randomized controlled trials, where authors report research in a way that potentially misrepresents results and mislead readers, has been demonstrated in the broader medical literature. We investigated spin in wound care trials with (a) no statistically significant result for the primary outcome and (b) no clearly specified primary outcome.
Methods: We searched the Cochrane Wounds Group Specialised Register of Trials for randomized controlled trials (RCTs).
Objectives: To establish reliable estimates of the proportion of books available in formats accessible to visually impaired people; to recommend a practical method of updating the estimates.
Methods: The project had two stages. Stage one estimated the overall availability of all categories of books.