Publications by authors named "Suzanne Hollingsworth"
Genes Cells
February 2021
Article Synopsis
- The process of DNA replication in E. coli is highly organized, but UV damage can disrupt this coordination, leading to potential genome instability and cell death.
- After UV exposure, replication initiations at the oriC region continue, causing an increase in DNA copies, but later delays in elongation create issues in completing replication, resulting in temporary over-replication.
- Mutants that struggle with elongation or completion of replication show different outcomes: some quickly degrade or remain stagnant in their genome status, while others experience delayed cell death due to the accumulation of imbalanced chromosomes during division.
