Publications by authors named "Suzanne Barker"
Article Synopsis
- People with rarer dementias struggle to find support and tailored information, but online meeting platforms can help them connect, especially during the COVID-19 pandemic.
- The study focuses on creating videoconferencing support groups for individuals with frontotemporal dementia, young-onset Alzheimer’s, and other conditions, detailing the process of development, testing, and evaluation.
- A three-phase approach was used to gather input from affected individuals, test the support groups with 154 participants, and develop an evaluation plan to refine future sessions based on gathered data and themes.
Article Synopsis
- - Preliminary research indicates that SARS-CoV-2 may harm the nervous system, prompting a study involving serum and cerebrospinal fluid (CSF) from 34 COVID-19 patients with neurological symptoms to determine the extent and nature of this damage.
- - Biomarkers of neuronal damage, particularly neurofilament light, were found at significantly higher levels in the CSF of patients with serious CNS conditions, like encephalitis, compared to other neurological conditions and control groups.
- - Elevated neurofilament light levels were present in hospitalized COVID-19 patients regardless of neurological symptoms, but no significant increases were observed in community cases, suggesting minimal neurological damage in milder cases; astrocytic activation was not linked to neuronal damage in
The European Bioanalysis Forum is providing a proposal on experiments to be conducted if processed samples are to be stored for a period of time, either after an initial injection or if processed samples are to be stored for a period of time prior to their first injection. Using survey information and extensive discussion an insight was gained as to whether the current practices employed during method validation were conducted to scientifically validate actual sample handling conditions or to simply meet a perceived regulatory expectation. The goal of this report is to recommend the adoption of scientifically justified validation experiments that exactly reproduce and processed test sample handling and storage procedures and to introduce some uniformity across the industry.
View Article and Find Full Text PDFOur understanding of the molecular mechanisms of many neurological disorders has been greatly enhanced by the discovery of mutations in genes linked to familial forms of these diseases. These have facilitated the generation of cell and animal models that can be used to understand the underlying molecular pathology. Recently, there has been a surge of interest in the use of patient-derived cells, due to the development of induced pluripotent stem cells and their subsequent differentiation into neurons and glia.
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