Publications by authors named "Suzanna Lonce"
Article Synopsis
- Obesity is linked to insulin resistance, affecting both glucose uptake and the body's blood vessel response to insulin, which is crucial for delivering glucose to tissues.
- A study tested the role of sympathetic activation in impaired insulin-triggered blood vessel dilation in obese adults using a controlled experiment with insulin and drugs to block sympathetic responses.
- Results showed that blocking sympathetic activation significantly improved blood flow and microvascular function when insulin was administered, indicating that sympathetic activity may hinder insulin's vascular effects in obesity.
Postural orthostatic tachycardia syndrome (POTS) is a common autonomic disorder of largely unknown etiology that presents with sustained tachycardia on standing, syncope and elevated norepinephrine spillover. Some individuals with POTS experience anxiety, depression and cognitive dysfunction. Previously, we identified a mutation, A457P, in the norepinephrine (NE; also known as noradrenaline) transporter (NET; encoded by SLC6A2) in POTS patients.
View Article and Find Full Text PDFBackground: Fava beans (Vicia faba) contain dihydroxyphenylalanine (dopa), and their ingestion may increase dopamine stores. Renal dopamine regulates blood pressure and blood volume via a natriuretic effect.
Objective: The objective was to determine the relation between dietary fava beans, plasma and urinary catechols, and urinary sodium excretion in 13 healthy volunteers.
Background: Norepinephrine (NE) is a primary neurotransmitter of central autonomic regulation and sympathetic nerve conduction, and the norepinephrine transporter (NET) is crucial in limiting catecholaminergic signaling. NET is sensitive to antidepressants, cocaine, and amphetamine. NET blockade often is associated with cardiovascular side effects, and NET deficiency is linked to tachycardia in familial orthostatic intolerance.
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