Colchicine inhibits heterotopic ossification: experimental study in rabbits.

Background: Heterotopic ossification is a common complication of hip surgery and musculoskeletal or brain trauma.

Objectives: To confirm by in vivo study that colchicine inhibits osteoblast cell proliferation with marked decrease in tissue mineralization.

Methods: Heterotopic ossification was induced in three groups of New Zealand white rabbits (females, 6 months old, weight 3-3.