Clinicopathological aspects of 25 cases of sialolithiasis of minor salivary glands.

Sialolithiasis of minor salivary glands (SMSG) is rarely reported and presumably represents an underestimated disease. This study examined the clinicopathological aspects of 25 selected SMSG cases over an 11-year period at the Oral Pathology Department of the University of Sao Paulo, Brazil. SMSG was not a clinical diagnosis in 92% of the cases.

Oestrogens and androgen receptors in oral squamous cell carcinoma.

Objective: To investigate the gender-related expressions of androgen (AR), estrogen alpha (ERα) and beta (ERβ) receptors and aromatase enzyme in oral squamous cell carcinomas (OSCC).

Materials And Methods: A total of 60 cases of OSCC (30 from males and 30 from females) were retrieved and submitted to immunohistochemistry. Also, steroid expression was studied in two OSCC cell lines using Western blotting and immunofluorescence.

Heterotopic gastrointestinal mucosa in the oral cavity of adults.

Heterotopic gastrointestinal mucosa (HGM) is a rare entity observed in the head and neck region and occurs more frequently in male infants and children. The floor of the mouth and anterior aspects of the tongue are the most commonly affected sites. Histologically, HGM resembles gastric, intestinal or colonic mucosa with areas of squamous epithelium, which can be cystic or solid.

Oral squamous cell carcinoma: an analysis of 1,564 cases showing advances in early detection.

The present study aimed to detect possible differences in the data of oral squamous cell carcinomas (OSCC) cases diagnosed in a Dental School in São Paulo city over the last 40 years. The records of patients diagnosed as having OSCC between the years 1960 and 2008 were retrieved. The whole period was divided into four time periods.

Correlation between c-Jun and human papillomavirus in oral premalignant and malignant lesions.

c-Jun, one of the components of the transcription factor activating protein-1 (AP-1), is suggested as a factor in malignant progression of oral lesions. c-Jun and other AP-1 components relationships with human papillomavirus (HPV) infection have been investigated, but not yet focusing on oral carcinogenesis. The aim of this study was to verify whether c-Jun immunohistochemical expression is related to HPV DNA detection in oral premalignant and malignant lesions.

Evaluation of proliferative potential in oral lichen planus and oral lichenoid lesions using immunohistochemical expression of p53 and Ki67.

A small proportion of cases diagnosed as oral lichen planus (OLP) and oral lichenoid lesions (OLL) can undergo malignant transformation. Some authors, however, stand that only dysplastic lichenoid lesions, not true OLP, have the potential to progress to oral squamous cell carcinoma (OSCC). The histologic diagnosis is a subjective resource and is not always accurate in differentiating OLP from OLL.

Assessment of c-Jun, c-Fos and cyclin D1 in premalignant and malignant oral lesions.

Unlabelled: Some oral cancers are known to develop from dysplastic oral epithelium. In the present study, the expression of c-Jun, c-Fos, and cyclin D1 proteins in oral epithelial lesions with different degrees of dysplasia, and in oral squamous cell carcinomas (OSCCs) was evaluated. Eighteen cases of mild dysplasia, 23 cases of moderate to severe dysplasia and 24 OSCCs were studied immunohistochemically.

Comparison between immunohistochemical expression of cyclin D1 and p21 and histological malignancy graduation of oral squamous cell carcinomas.

The objective of the present study was to correlate the expression of cyclin D1 with the expression of p21 in 28 cases of oral squamous cell carcinoma (OSCC), as well as to compare the expression of both with a histological graduation of this neoplasm. Immunohistochemistry was used to obtain the expression of cyclin D1 and p21. The results of statistical analysis showed no correlation between the expression of cyclin D1 and p21.

Compound odontoma in three dogs.

Three young, female dogs were operated for compound odontoma. All tumors were considered stage III with treatment consisting of partial mandibulectomy or maxillectomy. Microscopic examination of the resected tissue confirmed the diagnosis.

Altered cytokeratin expression in actinic cheilitis.

Background: Actinic cheilitis (AC) is a widely recognized precancerous lesion of the lip. Varying degrees of epithelial dysplasia may be present. However, no studies have correlated epithelial changes with cytokeratin expression that might reflect the disordered maturation that is probably occurring.

Immunohistochemical study of the orthokeratinized odontogenic cyst: a comparison with the odontogenic keratocyst.

Objective: Orthokeratinized odontogenic cyst (OOC) is a developmental cyst that occurs in the maxilla and the mandible and is defined by the World Health Organization as the uncommon orthokeratinized type of odontogenic keratocyst (OKC). However, studies have shown that OOC has peculiar clinicopathologic aspects and biologic behavior when compared with other developmental odontogenic cysts, especially OKCs. Therefore, in this study, the immunohistochemical profile of the OOC was delineated and compared with that of the OKC.

Immunolocalization of c-Fos and c-Jun in human oral mucosa and in oral squamous cell carcinoma.

Background: Studies have addressed the relevance of c-Jun and c-Fos proteins in cancer development. In the present study, the expression of c-Jun and c-Fos, the major components of transcription factor activator protein (AP1), were evaluated to determine possible alterations to these factors in oral squamous cell carcinoma (OSCC).

Methods: Fifteen cases of normal oral mucosa and 20 cases of OSCC were retrieved from the Archives of the Surgical Pathology Service at the University of São Paulo.