The early preclinical and clinical development of cipargamin (KAE609), a novel antimalarial compound.

Background: Cipargamin (KAE609) is a novel spiroindolone class drug for the treatment of malaria, currently undergoing phase 2 clinical development. This review provides an overview and interpretation of the pre-clinical and clinical data of this possible next-generation antimalarial drug published to date.

Methods: We systematically searched the literature for studies on the preclinical and clinical development of cipargamin.