Influence of ethephon and soil treatments on the essential oil composition of sweet fennel and its biological activities.

The manipulation of cultivation conditions in addition to environmental changes is a key factor affecting the growth, secondary metabolites production, and the biological activity of the plant. Our study aims to evaluate the impact of foliar spray of ethephon, water stress, organic and inorganic fertilizers on the cytotoxic and antimicrobial activities of the fruit oil of Foeniculum vulgare, Miller, var. dulce and its vegetative growth and oil composition.

In-Vitro Cytotoxic and Anti-Inflammatory Potential of Asparagus Densiflorus Meyeri and its Phytochemical Investigation.

Genus Asparagus is well known for its pharmacological activities and ethnopharmacological applications. In folk medicine, it is used in the management of several diseases such as diabetes, inflammations, and rheumatism. This work aimed to investigate the potential of Asparagus densiflorus meyeri root & aerial parts extracts as cytotoxic and anti-inflammatory and the investigation of their chemical profile.

Profiling of two species using LC-ESI/MS with evidence of their hepatoprotective activity.

and are only reported to have significant cytotoxic activity against certain cancer cell lines with phytochemical investigation of their petroleum ether and the ethyl acetate extracts. Further investigation was suggested concerning their hepatoprotective activity and relating it to the metabolic profile of their defatted methanol extracts using LC-ESI/MS analysis. Hepatoprotective activity was evaluated through assessment of three liver parameters as well as liver histopathological examination in thioacetamide-induced hepatotoxicity model.

Structural characterization of three cytotoxic steroidal saponins from the leaves of Agave desmetiana hort.

Three steroidal saponins detected by LC-MS were isolated from the leaves of Agave desmetiana hort. The three saponins were characterized as; Tigogenin 3 - [{O - β - D - xylopyranosyl (1 → 2) - α - L-rhamnopyranosyl (1 → 3)}-β-D- glucopyranoside), Tigogenin- 3 - ([O- α -L-rhamnopyranosyl (1 → 3) - β - D - glalactopyranosyl (1 → 2)] - β - D - glucopyranoside) and Tigogenin- 3 - ([{O - α - L - rhamnopyranosyl (1 → 4)} - β - D - galactopyranosyl (1 → 3) - β - D - xylopyranosyl (1 → 2)] - β - D - glucopyranoside). Identification and structure elucidation of the isolates were done via 1D and 2D NMR techniques, and chemical methods.

Phytochemical investigation of and family Aizoaceae and evaluation of their cytotoxic activity.

This study aims to shed light on the phytochemical composition and the biological effect of two members of family and Gas chromatography coupled to mass spectrometry (GC-MS) and high-performance liquid chromatography (HPLC) was used to investigate the lipoidal matter and the phenolic content, respectively. The MTT assay was used to evaluate the cytotoxic activity against MCF-7 (breast cancer), HepG2 (liver cancer) and HCT-116 (colorectal cancer) cell lines. The total phenolic acids and the total flavonoid content of were found to be higher than that of Phytol, hexadecanoic acid, -coumaric, ferulic and - hydroxybenzoic acids were the major detected compounds.

LC-ESI-MS/MS Alkaloidal Profiling and Biological Investigation of Stems.

is a succulent plant of the family, commonly known as the golden rat tail. Many members of the family are the focus of chemical and biological studies as they contain bioactive compounds, well known for their health-related properties. We aimed to investigate stems both phytochemically and biologically for the first time including three biological effects.

The anti-inflammatory, anti-ulcer activities and phytochemical investigation of L. cv. Ismailawi fruits.

This study aims to evaluate the anti-inflammatory and anti-ulcer activities of L. cv. Ismailawi fruits, as well as the investigation of the phenolic content and lipoidal matter composition via high performance liquid chromatography and gas chromatography coupled to mass spectrometry respectively.

LC-ESI-MS/MS profiling of alkaloids and antiproliferative activity of drake leaves.

In the present study, evaluation of the antiproliferative activity of Drake leaves (family Apocyaceae) against human breast cancer cell lines MDA-MB-231 was done for the total methanolic extract, crude alkaloidal mixture and ursolic acid using the MTT colorimetric assay. The methanolic extract showed the strongest antiproliferative activity followed by ursolic acid and crude alkaloidal fraction with an IC equal to 6.2, 14.

LC/ESI-MS/MS profiling of Ulmus parvifolia extracts and evaluation of its anti-inflammatory, cytotoxic, and antioxidant activities.

In this study, a comparative liquid chromatography/mass spectroscopy (LC/ESI-MS/MS) profiling of different fractions of Ulmus parvifolia leaves and stems was performed. Identification of compounds was based on comparing the mass spectrometric information obtained including m/z values and individual compound fragmentation pattern to tandem mass spectral library search and literature data. Eleven compounds were tentatively identified in the different analyzed fractions.