Publications by authors named "SuzAnn Hertzler"
Article Synopsis
- The study focuses on analyzing unknown impurities in degraded paromomycin topical cream using advanced techniques like ultra-high-performance liquid chromatography and tandem mass spectrometry (UHPLC/MS/MS).
- A new method was developed to efficiently measure paromomycin potency and identify impurities, separating two isomers and twelve unknown impurity peaks, with further identification of six impurities through mass spectrometry.
- Ultimately, nine impurities were identified, revealing modifications such as carbamylation, acetylation, and others, with the most prominent being carbamylation linked to urea from the cream's formulation.