Scalable and Structural Multi-View Graph Clustering With Adaptive Anchor Fusion.

Anchor graph has been recently proposed to accelerate multi-view graph clustering and widely applied in various large-scale applications. Different from capturing full instance relationships, these methods choose small portion anchors among each view, construct single-view anchor graphs and combine them into the unified graph. Despite its efficiency, we observe that: (i) Existing mechanism adopts a separable two-step procedure-anchor graph construction and individual graph fusion, which may degrade the clustering performance.

Angiogenin-mediated tsRNAs control inflammation and metabolic disorder by regulating NLRP3 inflammasome.

The cellular stress response system in immune cells plays a crucial role in regulating the development of inflammatory diseases. In response to cellular damage or microbial infection, the assembly of the NLRP3 inflammasome induces pyroptosis and the release of inflammatory cytokines. Meanwhile, Angiogenin (Ang)-mediated transfer RNA-derived small RNAs (tsRNAs) promote cell survival under stressful conditions.

Ribosome-targeting antibiotic control NLRP3-mediated inflammation by inhibiting mitochondrial DNA synthesis.

While antibiotics are designed to target bacteria specifically, most are known to affect host cell physiology. Certain classes of antibiotics have been reported to have immunosuppressive effects, but the underlying mechanisms remain elusive. Here, we show that doxycycline, a ribosomal-targeting antibiotic, effectively inhibited both mitochondrial translation and nucleotide-binding domain and leucine-rich repeat-containing protein 3 (NLRP3) inflammasome-mediated caspase-1 activation and interleukin-1β (IL-1β) production in bone-marrow-derived macrophages (BMDMs).

Sparse Low-Rank Multi-View Subspace Clustering With Consensus Anchors and Unified Bipartite Graph.

Anchor technology is popularly employed in multi-view subspace clustering (MVSC) to reduce the complexity cost. However, due to the sampling operation being performed on each individual view independently and not considering the distribution of samples in all views, the produced anchors are usually slightly distinguishable, failing to characterize the whole data. Moreover, it is necessary to fuse multiple separated graphs into one, which leads to the final clustering performance heavily subject to the fusion algorithm adopted.

Bile acids ameliorates lipopolysaccharide-induced endometritis in mice by inhibiting NLRP3 inflammasome activation.

Aims: Endometritis is a common inflammatory disorder affecting the reproductive health in both humans and livestock. The NLR family pyrin domain containing 3 (NLRP3) inflammasome has recently been identified as a possible therapeutic target for several inflammatory disorders. Bile acids (BAs) have been shown to possess anti-inflammatory properties by inhibiting the activation of the NLRP3 inflammasome.

Regularized Simple Multiple Kernel k-Means With Kernel Average Alignment.

Multiple kernel clustering (MKC) aims to learn an optimal kernel to better serve for clustering from several precomputed basic kernels. Most MKC algorithms adhere to a common assumption that an optimal kernel is linearly combined by basic kernels. Based on a min-max framework, a newly proposed MKC method termed simple multiple kernel k -means (SimpleMKKM) can acquire a high-quality unified kernel.

Fast Incomplete Multi-View Clustering With View-Independent Anchors.

Multi-view clustering (MVC) methods aim to exploit consistent and complementary information among each view and achieve encouraging performance improvement than single-view counterparts. In practical applications, it is common to obtain instances with partially available information, raising researches of incomplete multi-view clustering (IMC) issues. Recently, several fast IMC methods have been proposed to process the large-scale partial data.

Small Noncoding RNAs Contribute to Sperm Oxidative Stress-Induced Programming of Behavioral and Metabolic Phenotypes in Offspring.

There is growing evidence that paternal environmental information alters small noncoding RNAs (sncRNAs) in sperm and in turn can induce alterations of metabolic and behavioral phenotypes of the next generation. However, the potential mediators of the effects remain to be elucidated. A great diversity of environmental insults and stresses can convergently induce the elevation of reactive oxygen species (ROS) in sperm; nonetheless, it remains unclear whether ROS mediates the biogenesis of sncRNAs in sperm and participates in the reprogramming of offspring phenotypes.

Parameter-Free and Scalable Incomplete Multiview Clustering With Prototype Graph.

Multiview clustering (MVC) seamlessly combines homogeneous information and allocates data samples into different communities, which has shown significant effectiveness for unsupervised tasks in recent years. However, some views of samples may be incomplete due to unfinished data collection or storage failure in reality, which refers to the so-called incomplete multiview clustering (IMVC). Despite many IMVC pioneer frameworks have been introduced, the majority of their approaches are limited by the cubic time complexity and quadratic space complexity which heavily prevent them from being employed in large-scale IMVC tasks.

The individual N- and C-lobes of calmodulin tether to the Cav1.2 channel and rescue the channel activity from run-down in ventricular myocytes of guinea-pig heart.

The present study examined the binding of the individual N- and C-lobes of calmodulin (CaM) to Cav1.2 at different Ca(2+) concentration ([Ca(2+)]) from ≈ free to 2mM, and found that they may bind to Cav1.2 Ca(2+)-dependently.

Lentiviral delivery of biglycan promotes proliferation and increases osteogenic potential of bone marrow-derived mesenchymal stem cells in vitro.

Mesenchymal stem cells (MSCs) are multipotent progenitor nonhematopoietic cells that have emerged as an attractive cell source for tissue engineering. Biglycan (BGN), an extracellular matrix component, has been reported to play a crucial role in bone formation. However, the role of BGN in MSCs remains unknown.

The effects of chronic aluminum exposure on learning and memory of rats by observing the changes of Ras/Raf/ERK signal transduction pathway.

Objective: To investigate the effects of chronic aluminum (Al) exposure on learning and memory function of rats by observing the changes of Ras/Raf/ERK (Ras/ERK) signaling pathway.

Methods: Eighty weaned Wistar rats were divided into four groups ad libitum, 20 rats in each group. The four groups were fed with drinking water containing 0% (control), 0.

Supplementation of konjac glucomannan into a low-fiber Chinese diet promoted bowel movement and improved colonic ecology in constipated adults: a placebo-controlled, diet-controlled trial.

Objectives: This diet-controlled study was designed to examine effects of konjac glucomannan (KGM) supplement on the bowel habits and colonic ecology in 7 constipated subjects. In addition, the mechanisms by which KGM modulated the bowel habit were explored.

Methods: Seven constipated subjects who passed bowel movement less than once a day participated in this diet-controlled linear study that consisted of a 21-d placebo period, a 7-d adaptation period, and a 21-d KGM-supplemented (1.

Konjac acts as a natural laxative by increasing stool bulk and improving colonic ecology in healthy adults.

Objective: Konjac glucomannan (KGM) has been shown to relieve constipation, which could be associated with increased stool bulk and improved colonic ecology.

Methods: This placebo-controlled study consisted of a 21-d placebo period, a 7-d adaptation period when volunteers consumed KGM progressively, and a 21-d KGM-supplemented period (1.5 g/meal, 4.

[Effect of lead on learn and memory and release of intracellular free Ca2+ from calcium pool in dissociated mouse hippocampal neurons].

Objective: To study effect of lead on learn and memory and the release of intracellular free Ca2+ from calcium pool in dissociated mouse hippocampal neurons.

Methods: Using a water maze we measured the ability of spatial learning of mouses. Digesting with low concentration of trypsin and gently triturating mode were used to dissociate hippocampal neurons.