Publications by authors named "Suyu Zong"

Article Synopsis
  • The study focuses on a common fusion gene in childhood acute lymphoblastic leukemia (ALL) which is generally linked to better outcomes, but about 10% of affected children still experience early relapses with poor survival rates.
  • Researchers analyzed data from 87 low-risk B-cell ALL children to identify factors predicting early relapse, highlighting that high gene expression at diagnosis is a key independent predictor.
  • Validation studies reinforced that high expression at diagnosis not only correlates with increased relapse risk in low-risk fusion gene-positive children but also in low-risk fusion gene-negative children, suggesting a broader implication for treatment strategies.
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Purpose: Patient-tailored minimal residual disease (MRD) monitoring based on circulating tumor DNA (ctDNA) sequencing of leukemia-specific mutations enables early detection of relapse for pre-emptive treatment, but its utilization in pediatric acute myelogenous leukemia (AML) is scarce. Thus, we aim to examine the role of ctDNA as a prognostic biomarker in monitoring response to the treatment of pediatric AML.

Experimental Design: A prospective longitudinal study with 50 children with AML was launched, and sequential bone marrow (BM) and matched plasma samples were collected.

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Lysine methyltransferase 2A-rearranged acute myeloid leukemia (-r AML) is a special entity in the 2022 World Health Organization classification of myeloid neoplasms, characterized by high relapse rate and adverse outcomes. Current risk stratification was established on the treatment response and translocation partner of . To study the transcriptomic feature and refine the current stratification of pediatric -r AML, we analyzed clinical and RNA sequencing data of 351 patients.

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Article Synopsis
  • * Two main evolutionary patterns identified in T-ALL are "clonal shift," where new clones emerge, and "clonal drift," where existing clones continue to evolve.
  • * The RNA-binding protein MSI2 was found to be significantly upregulated in persistent TCR clonotypes at relapse, suggesting it plays a role in tumor growth and chemotherapy resistance, making it a potential new target for treatment.
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Background: Acute myeloid leukemia (AML) and hyperleukocytosis have an unfavorable prognosis, but the impact of hyperleukocytosis on the prognosis of pediatric AML remains uncertain. We investigated the clinical characteristics and prognosis of pediatric AML with hyperleukocytosis, defined as WBC ≥ 50 × 10/L.

Methods: A total of 132 patients with newly diagnosed childhood AML with hyperleukocytosis were consecutively enrolled at our center from September 2009 to August 2021 to investigate prognostic factors and clinical outcomes.

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Background: Natural killer (NK) cells are a subtype of lymphocytes with the ability to quickly and efficiently identify and eliminate tumor cells. In the presence of IL2, NK cells can divide rapidly but in limited numbers. According to previous studies, in vivo treatment with histone deacetylase (HDAC) inhibitors did not impair NK-cell function.

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Objectives: To investigate the distribution of body mass index (BMI) and risk factors for obesity in children with Diamond-Blackfan Anemia (DBA).

Methods: The children with DBA who attended National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, from January 2003 to December 2020 were enrolled as subjects. The related clinical data and treatment regimens were recorded.

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Non-Down's syndrome acute megakaryocytic leukemia (non-DS-AMKL) is a subtype of childhood acute myeloid leukemia (AML), whose prognosis, prognostic factors and treatment recommendations have not yet to be defined in children. We conducted a retrospective study with 65 newly diagnosed non-DS-AMKL children from August 2003 to June 2020 to investigate the clinical impact of factors and clinical outcome. Among all 65 patients, 47 of them were treated at our center who received three different regimens due to time point of admission (CAMS-another, CAMS-2009 and CAMS-2016 protocol), and the efficacy were compared.

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Article Synopsis
  • This study focused on the link between paroxysmal nocturnal hemoglobinuria (PNH) clones and the effectiveness of immunosuppressive therapy (IST) in children with severe aplastic anemia (SAA).
  • It involved analyzing medical data from 151 children, where 135 were negative for PNH clones and 16 were positive, to see how these factors influenced treatment outcomes.
  • Findings indicated that children with positive PNH clones had a poorer overall response to IST over time and a higher risk of developing a specific syndrome related to both conditions.
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  • Minimal residual disease (MRD) after chemotherapy is a key indicator for predicting outcomes in cancers, but understanding its resistance mechanisms is challenging due to the rarity and variety of these residual cells.
  • Researchers conducted a study analyzing over 161,000 single-cell transcriptomes to examine changes in B-cell acute lymphoblastic leukaemia (B-ALL) from diagnosis to relapse and residual states.
  • They found that relapse leukaemic cells often became less differentiated, and residual cells activated a hypoxia pathway, which when inhibited, made the leukaemic cells more responsive to chemotherapy, offering new treatment possibilities for B-ALL.
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Objective: To systematically describe the short stature of patients with Diamond-Blackfan anemia and to explore factors affecting the height development of patients with Diamond-Blackfan anemia.

Study Design: This cross-sectional study was conducted at the Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, and the height, weight, and clinical data of 129 patients with Diamond-Blackfan anemia were collected from June 2020 to September 2020.

Results: The median height-age-z score (HAZ) of children affected by Diamond-Blackfan anemia was -1.

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Relapse of childhood AML1-ETO (AE) acute myeloid leukemia is the most common cause of treatment failure. Optimized minimal residual disease monitoring methods is required to prevent relapse. In this study, we used next-generation sequencing to identify the breakpoints in the fusion gene and the DNA-based droplet digital PCR (ddPCR) method was used for dynamic monitoring of AE-DNA.

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Macrophage-orchestrated chronic inflammation plays an important role in cardiovascular disease, including accelerating the development of calcific aortic valve disease (CAVD). M1 and M2 macrophage polarization imbalances can alter intensity of inflammatory responses. Recombinant human interleukin 37 (IL-37) could be involved in regulating immune cell function to attenuate inflammation.

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