Siamese and triplet network-based pain expression in robotic avatars for care and nursing training.

Care and nursing training (CNT) refers to developing the ability to effectively respond to patient needs by investigating their requests and improving trainees' care skills in a caring environment. Although conventional CNT programs have been conducted based on videos, books, and role-playing, the best approach is to practice on a real human. However, it is challenging to recruit patients for continuous training, and the patients may experience fatigue or boredom with iterative testing.

Safety, pharmacokinetics, and pharmacodynamics of a next-generation subcutaneously administered coagulation factor IX variant, dalcinonacog alfa, in previously treated hemophilia B patients.

Background: Dalcinonacog alfa (DalcA), a next-generation, recombinant human factor IX (FIX) variant, was developed using a rational design approach for increased procoagulant activity and longer duration of action to be administered subcutaneously (SC) for prophylaxis of hemophilia B bleeding episodes.

Objectives: To investigate the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of DalcA.

Methods: This multicenter, phase 1/2a study (NCT03186677) was conducted in 11 males aged 12 to 65 years with severe hemophilia B.

Effects of Apigenin on RBL-2H3, RAW264.7, and HaCaT Cells: Anti-Allergic, Anti-Inflammatory, and Skin-Protective Activities.

Apigenin (4',5,7-trihydroxyflavone, flavonoid) is a phenolic compound that is known to reduce the risk of chronic disease owing to its low toxicity. The first study on apigenin analyzed its effect on histamine release in the 1950s. Since then, anti-mutation and antitumor properties of apigenin have been widely reported.

In Vitro Study on the Plasma-Polymerization of Propionaldehyde and Allylglycidyl Ether for Immobilization of Recombinant Human Bone Morphogenetic Protein-2.

In this study, recombinant human bone morphogenetic protein-2 (rhBMP-2) was directly immobilized on the plasma-polymerized propionaldehyde (PA) and allylglycidyl ether (AGE) surface through the imine bonding and epoxy-amine bonding, respectively. Aldehyde and epoxide plasma-polymerization were carried out at plasma power 60 W for 10 min and monomers were used to PA and AGE. After the plasma-polymerization and rhBMP-2 immobilization, substrate surfaces were characterized by contact angle, field emission scanning electron microscopy, and attenuated total reflectance Fourier transform infrared.