Publications by authors named "Suyama P Mihindukulasooriya"
Sargassum horneri extract containing polyphenol alleviates DNCB-induced atopic dermatitis in NC/Nga mice through restoring skin barrier function.
Suyama Prasansali Mihindukulasooriya Duong Thi Thuy Dinh Kalahe Hewage Iresha Nadeeka Madushani Herath Hyo Jin Kim Eui-Jeong Han
Histol Histopathol
September 2022
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by skin barrier dysfunction. Sargassum horneri (S. horneri) is a brown alga that has been widely used in traditional medicine of eastern Asian countries.
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- The study investigated the anti-obesity effects of sulforaphane (SFN) and glucoraphanin (GRN) found in broccoli leaf extract (BLE) on fat cells (3T3-L1 adipocytes) and genetically modified obese mice (ob/ob).
- Findings showed that SFN and BLE significantly decreased fat storage and triglyceride levels in both the cells and the mice.
- Additionally, treatment with SFN and BLE improved lipid metabolism by altering the expression of several key genes and reducing fat-related blood markers, indicating a potential therapeutic role against obesity.
Sargassum horneri extract containing mojabanchromanol attenuates the particulate matter exacerbated allergic asthma through reduction of Th2 and Th17 response in mice.
Kalahe Hewage Iresha Nadeeka Madushani Herath Hyo Jin Kim Suyama Prasansali Mihindukulasooriya Areum Kim Hyun Jung Kim
Environ Pollut
October 2020
Airborne particulate matter (PM) has become a serious health issue causing pulmonary diseases such as asthma. Due to the side effects and non-specificity of conventional drugs, there is a need to develop natural-product-based alternative treatments. Sargassum horneri is a brown alga shown to have anti-oxidant, anti-inflammatory, and anti-allergic effects.
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