Front Neural Circuits
September 2024
Biomass fly ash is a sustainable, eco-friendly cement substitute with economic and performance benefits, being renewable compared to coal fly ash. This study examines using biomass fly ash (BFA) as a sustainable cement substitute, comparing it with Class F fly ash (CFA). With a water-binder ratio of 0.
View Article and Find Full Text PDFDecreased attentional function causes problems in daily life. However, a quick and easy evaluation method of attentional function has not yet been developed. Therefore, we are searching for a method to evaluate attentional function easily and quickly.
View Article and Find Full Text PDFWe present a novel study introducing a durable and robust covalent-organic framework (COF) nanocoating, developed on living cells. This COF nanocoating demonstrates remarkable resistance against a diverse range of lethal stressors, including high temperature, extreme pH, ultraviolet radiation, toxic metal ions, organic pollutants, and strong oxidative stress. Notably, the nanocoating exhibits exceptional cell survival enhancement under high temperature and strongly acidic conditions, an aspect yet unexplored in the case of metal-organic framework nanocoatings and other nanomaterials.
View Article and Find Full Text PDFThe rapid expansion of construction, fueled by industry and economic and population growth, has exacerbated the challenge of managing construction waste, especially concrete waste. One promising solution lies in the utilization of recycled fine aggregate (RFA), especially in combination with the emerging geopolymer technology, an innovative alternative to traditional cement. This study systematically explores the effects of incorporating varying qualities and quantities of RFA into geopolymer mortars.
View Article and Find Full Text PDFPertussis, commonly known as whooping cough is a severe respiratory disease caused by the bacterium, . Despite widespread vaccination, pertussis resurgence has been observed globally. The development of the current acellular vaccine (ACV) has been based on planktonic studies.
View Article and Find Full Text PDFBackground: Management of a bladder tumor during pregnancy is an uncommon clinical situation. Leiomyosarcoma of the urinary bladder is a rare histological type of bladder tumor and a rare secondary cancer in survivors of retinoblastoma (RB). However, there has been no report of RB-associated bladder leiomyosarcoma during pregnancy.
View Article and Find Full Text PDFCuring temperature affects the compressive strength of cement paste systems via the pozzolanic reaction. However, different processes, climates, and weather conditions often result in different initial curing temperatures. The relationship between curing temperature and compressive strength is still an underexplored domain.
View Article and Find Full Text PDFWith the rapid development of urbanization, the construction industry consumes a lot of cement and produces a large amount of construction waste. To overcome this situation, the rational use of recycled aggregate produced from waste concrete is one of solutions. In some countries, the building industry has approved the use of recycled coarse aggregates in concrete, with some limits.
View Article and Find Full Text PDFIntroduction: Testicular ectopia refers to abnormal positioning of testis, which includes a wide variety of variants. An ectopic testis is located off the normal path of male gonadal descent, unlike conventional undescended testis.
Case Presentation: A 37-year-old man presented with the complaint of a palpable lesion in the scrotum.
Bordetella bronchiseptica (B. bronchiseptica) is associated with respiratory tract infections in laboratory animals. In our laboratory animal facility, B.
View Article and Find Full Text PDFThe unburned carbon in fly ash inhibits the performance of concrete. A device using the flotation method to remove unburned carbon in fly ash was developed, and the operating condition of the device was experimentally examined. According to the results, the device was able to remove unburnt carbon from fly ash by using the installed micro bubble nozzles and a whirl-type pump.
View Article and Find Full Text PDFSocial discrimination in rats requires activation of the intrinsic bulbar vasopressin system, but it is unclear how this system comes into operation, as olfactory nerve stimulation primarily inhibits bulbar vasopressin cells (VPCs). Here we show that stimulation with a conspecific can activate bulbar VPCs, indicating that VPC activation depends on more than olfactory cues during social interaction. A series of in vitro electrophysiology, pharmacology and immunohistochemistry experiments implies that acetylcholine, probably originating from centrifugal projections, can enable olfactory nerve-evoked action potentials in VPCs.
View Article and Find Full Text PDFThe intrinsic vasopressin system of the olfactory bulb is involved in social odor processing and consists of glutamatergic vasopressin cells (VPCs) located at the medial border of the glomerular layer. To characterize VPCs in detail, we combined various electrophysiological, neuroanatomical, and two-photon Ca imaging techniques in acute bulb slices from juvenile transgenic rats with eGFP-labeled VPCs. VPCs showed regular non-bursting firing patterns, and displayed slower membrane time constants and higher input resistances versus other glutamatergic tufted cell types.
View Article and Find Full Text PDFRNA interference (RNAi) can inhibit Influenza A virus (IAV) infection in a gene-specific manner. In this study, we constructed a transgene expressing a short hairpin RNA (shRNA) that targets the noncoding region of the IAV RNA gene encoding nucleoprotein (NP). To investigate the antiviral effects of the shRNA, we generated two transgenic mouse lines with this transgene.
View Article and Find Full Text PDFHerpesvirus entry mediator A (HVEM), nectin-1 and nectin-2 are cellular receptors of glycoprotein D (gD) of herpes simplex virus type-2 (HSV-2). It has been shown that soluble forms of HSV gD receptors have the antiviral potential in cultured cells and transgenic mice. Here, to compare antiviral potential of soluble forms of HVEM, nectin-1 and nectin-2 against HSV-2 infections in vivo, transgenic mice expressing fusion proteins consisting of the entire ectodomain of HVEM, nectin-1 or nectin-2 and the Fc portion of human IgG (HVEMIg, nectin-1Ig and nectin-2Ig, respectively) were intraperitoneally infected with HSV-2.
View Article and Find Full Text PDFGroup B Streptococcus (GBS) is a leading cause of invasive bacterial infections in human newborns. A key GBS virulence factor is its capsular polysaccharide (CPS), possessing terminal sialic acid residues that suppress host immune response and provide a survival advantage to the pathogen. CPS binds to Siglec-9 expressed on neutrophils, which is expected to down-regulate the immune responsiveness of neutrophils.
View Article and Find Full Text PDFThe nucleoprotein (NP) possesses regions that are highly conserved among influenza A viruses, and has therefore been one of the target viral proteins for development of a universal influenza vaccine. It has been expected that human or humanized antibodies will be made available for the prophylaxis, pre-emptive and acute treatment of viral infection. However, it is still unclear whether anti-NP human antibody can confer protection against influenza virus infection.
View Article and Find Full Text PDFThis study investigated the knockdown (KD) of Kid on maturation developmental competence and multinucleation of mouse germinal vesicle (GV) oocytes after parthenogenetic activation. Data revealed that Kid messenger RNA (mRNA) was expressed in GV and MII stage oocyte and 1- and 2-cell embryos. Additionally, Kid mRNA expression in the Kid KD group decreased by nearly 46% compared to the control small interfering RNA (siRNA) groups.
View Article and Find Full Text PDFTransgenic mouse lines expressing a soluble form of human nectin-2 (hNectin-2Ig Tg) exhibited distinctive elevation of amylase and lipase levels in the sera. In this study, we aimed to clarify the histopathology and to propose the transgenic mouse lines as new animal model for characteristic pancreatic exocrine defects. The significant increase of amylase and lipase levels in sera of the transgenic lines approximately peaked at 8 weeks old and thereafter, plateaued or gradually decreased.
View Article and Find Full Text PDFTumor-associated MUC1 binds to Siglec-9, which is expected to mediate tumor cell growth and negative immunomodulation. We hypothesized that a soluble form of Siglec-9 (sSiglec-9) competitively inhibits a binding of MUC1 to its receptor molecules like human Siglec-9, leading to provide antitumor benefit against MUC1-expressing tumor, and generated transgenic mouse lines expressing sSiglec-9 (sSiglec-9 Tg). When mammary tumor cells expressing MUC1 were intraperitoneally transplanted into sSiglec-9 Tg, tumor proliferation was slower with the lower histological malignancy as compared with non-transgenic mice.
View Article and Find Full Text PDFThe rupture of spontaneous dissecting coronary artery pseudoaneurysms is rare, and no standard therapy has yet been established for this condition. This report describes a case of a ruptured spontaneous dissecting coronary artery pseudoaneurysm in a patient with cardiac tamponade that was successfully treated with emergent implantation of a covered stent.
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