Publications by authors named "Suxia Wang"

Our objective was to clarify the pathological characteristics of native kidney biopsies and their association with clinical findings in patients with increased serum creatinine. Patients with elevated serum creatinine at native renal biopsy were included. Demographics, clinical details, and pathological findings of kidney biopsies were collected.

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Background: Patients with C3 glomerulopathy (C3G) often have a history of infection, which implies that infection may lead to abnormal activation of the complement alternative pathway (CAP) and induce the development of C3G. However, patients with postinfectious glomerulonephritis (PIGN) often have a low serum C3 concentration and positive glomerular C3 staining, consistent with the activation of the CAP. PIGN, especially if it involves simultaneous IgA deposition, is often difficult to differentiate from C3G.

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Aims: Calcified chondroid mesenchymal neoplasm (CCMN) is a recently identified category of soft tissue neoplasms defined by cartilage or cartilaginous matrix formation and gene fusions. Its rarity and similarities to other soft tissue tumours pose diagnostic challenges. This study aims to deepen understanding of CCMN, highlighting molecular pathology's role in diagnosis to reduce misdiagnosis, overdiagnosis and overtreatment.

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The tertiary structure of normal podocytes prevents protein from leaking into the urine. However, observing the complexity of podocytes is challenging because of the scale differences in their three-dimensional structure and the close proximity between neighboring cells in space. In this study, we explored podocyte-secreted angiopoietin-like 4 (ANGPTL4) as a potential morphological marker via super-resolution microscopy (SRM).

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Introduction: Idiopathic membranous nephropathy (iMN) has become one of the most prevalent primary glomerular diseases, with a marked increase in prevalence over the past two decades in northern China. Fine particulate matter (PM2.5) is considered to be associated with this rising prevalence.

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  • Mutation of the MMACHC gene causes cobalamin C disease (cblC), leading to symptoms like metabolic disorders and kidney issues, including thrombotic microangiopathy (TMA).
  • Three teenage patients were diagnosed with renal complications from cblC, showing symptoms such as hematuria and hypertension, with tests confirming elevated homocysteine and kidney damage.
  • Early diagnosis and treatment with hydroxocobalamin, betaine, and L-carnitine significantly improved their condition, underscoring the need for awareness of cblC in patients with unexplained kidney injury.
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  • The study examined the activation of the NLRP3 inflammasome pathway and macrophage distribution in patients with acute oxalate nephropathy (AON) compared to acute tubulointerstitial nephritis (ATIN).
  • In AON patients, significant increases in inflammation and NLRP3-related markers were observed, along with a notable presence of oxalate deposits and more severe tissue damage compared to ATIN patients.
  • A lower ratio of M1 to M2 macrophages was linked to worse kidney function and chronic lesions, suggesting the need for further research on these macrophage dynamics in kidney injury.
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Rationale & Objective: Postpartum renal cortical necrosis (postpartum RCN) is a severe form of obstetric acute kidney injury. This study aimed to identify clinicopathologic features in Chinese postpartum RCN cases to determine how pathologic findings may contribute to the treatment and prognosis.

Study Design: Single-center, case series.

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Objective: To explore the effect of information-motivation-behavioral skills model (IMB)-based continuous nursing model on the out-of-hospital rehabilitation of diabetic foot ulceration (DFU) patients, and to provide a theoretical basis for long-term disease management of DFU patients.

Methods: A total of 88 patients with DFU admitted to our Hospital were included in this prospective study. The patients were divided into control and study groups using the random number table method, with 44 cases in each group.

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Defects in the mitochondrial tRNA genes cause a group of highly clinically and genetically heterogeneous disorders, which poses a challenge for clinical identification and genetic diagnosis. Here, we present a pre-school boy with a novel MT-TD variant m.7560T>C at the heteroplasmy level of 76.

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  • Podocyte injury is crucial in the progression of diabetic nephropathy (DN), and this study investigates its relationship with proteinuria levels and DN classification in type 2 diabetes patients.
  • Researchers analyzed data from 110 patients, focusing on podocyte characteristics like foot process width (FPW) and podocyte detachment (PD) to assess their correlation with proteinuria severity and pathology.
  • Findings showed that wider FPW and higher PD percentages were linked to more severe proteinuria and advanced DN classifications, indicating that podocyte damage worsens kidney function in diabetic patients.
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Primary coenzyme Q10 deficiency-1, caused by COQ2 disease-causing variants, is an autosomal recessive disorder, and genetic testing is the gold standard for diagnosing this condition. A Chinese boy with steroid-resistant nephrotic syndrome, focal segmental glomerulosclerosis, and progressive kidney insufficiency was included in the study. Electron microscopy revealed the glomerular basement membrane with irregular thickness and lamellation with diffuse effacement of foot processes in the podocytes, and swollen mitochondria with abnormal cristae in the podocytes.

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Objectives: Calcium oxalate (CaOx) crystal deposition in acute kidney injury (AKI) patients is under recognized but impacts renal outcomes. This study investigates its determinants and effects.

Methods: We studied 814 AKI patients with native kidney biopsies from 2011 to 2020, identifying CaOx crystal deposition severity (mild: <5, moderate: 5-10, severe: >10 crystals per section).

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  • Hot Executive Function (hot EF) involves cognitive processes tied to emotions and motivation, mainly linked to specific areas in the brain like the ventromedial and orbitofrontal lobes.
  • The study examines how rhythmic-movement activities, paired with rewards, can impact the development of hot EF in children aged 5-6 years old, using a group of 62 participants from a kindergarten in Yantai, China.
  • Results indicated that engaging in rhythmic-movement activities with rewards significantly improved children's ability to delay gratification and make affective decisions, highlighting the positive effects of such interventions on hot EF development.
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In this paper, neural network control of fractional order chaotic systems (FOCSs) with input saturation and unknown sign of the controller gain is addressed by employing the Nussbaum function, where neural networks are utilized to model system uncertainties. To get rid of the limitation that reaching phase should be active before sliding motion in the traditional sliding mode control, a stable sliding surface is constructed. Then, by using the integer order Nussbaum gain control method, a novel controller with neural network sliding mode variable structure is designed.

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Light-chain proximal tubulopathy (LCPT) is a rare disease characterized by the accumulation of monoclonal light chains within proximal tubular cells. This study aimed to investigate the clinical characteristics of LCPT from a single Chinese nephrology referral center. Patients with kidney biopsy-proven isolated LCPT between 2016 and 2022 at Peking University First Hospital were retrospectively included.

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Background: Nephritis is a common manifestation of IgA vasculitis and is morphologically indistinguishable from IgA nephropathy. While MEST-C scores are predictive of kidney outcomes in IgA nephropathy, their value in IgA vasculitis nephritis has not been investigated in large multiethnic cohorts.

Methods: Biopsies from 262 children and 99 adults with IgA vasculitis nephritis ( N =361) from 23 centers in North America, Europe, and Asia were independently scored by three pathologists.

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Unexplained recurrent spontaneous abortion (URSA) is a common complication of pregnancy that affects the health of pregnant women. Deficient endometrial decidualization has been associated with URSA. However, the underlying mechanism is poorly understood.

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Background: The prognostic value and response to immunosuppressive therapy (IST) of patients with crescents in the different backgrounds of pathological presentations in immunoglobulin A nephropathy (IgAN) is unclear.

Methods: A total of 1262 IgAN patients were enrolled. Crescents (C, 0/1/2), fibrinoid necrosis (FN, 0/1) and endocapillary hypercellularity (E, 0/1) were integrated into different degrees of glomerular activity (0-4 points): mild (0), moderate (1-2) and severe (≥3).

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Objectives: Unexplained recurrent spontaneous abortion (URSA) remains an intractable reproductive dilemma due to the lack of understanding of the pathogenesis. This study aimed to evaluate the preclinical evidence for the mesenchymal stromal cell (MSC) treatment for URSA.

Methods: A meticulous literature search was independently performed by two authors across the Cochrane Library, EMBASE, and PubMed databases from inception to April 9, 2023.

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Introduction: Diabetic kidney disease (DKD), one of the leading causes of end-stage renal disease, has complex pathogenic mechanisms and few effective clinical therapies. DKD progression is accompanied by the loss of renal resident cells, followed by chronic inflammation and extracellular matrix deposition. Necroptosis is a newly discovered form of regulated cell death and is a major form of intrinsic cell loss in certain diabetic complications such as cardiomyopathy, intestinal disease, and retinal neuropathy; however, its significance in DKD is largely unknown.

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Synopsis of recent research by authors named "Suxia Wang"

  • - Suxia Wang's recent research primarily explores various renal disorders, including unique genetic mutations associated with conditions like gelsolin amyloidosis and cobalamin C disease, emphasizing the importance of genetic testing in the diagnosis and management of kidney diseases.
  • - A notable focus is on the histopathological and clinicopathological characteristics of nephropathies, such as acute oxalate nephropathy and type 2 diabetic nephropathy, revealing significant associations between specific pathological changes and clinical outcomes, including proteinuria.
  • - Wang also investigates interdisciplinary approaches in patient management, such as using behavioral models for diabetic foot ulcer rehabilitation, suggesting that tailored nursing strategies could improve long-term patient outcomes.

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