New 1,2,3-Triazole-genipin Analogues and Their Anti-Alzheimer's Activity.

A novel series of 1,2,3-triazole-genipin analogues were designed, synthesized, and evaluated for neuroprotective activity, acetylcholinesterase (AChE), and butyrylcholinesterase (BuChE) inhibitory activity. The genipin analogues bearing bromoethyl- and diphenylhydroxy-triazole showed neuroprotective properties against HO toxicity along with potent inhibitory activity on BuChE with IC values of 31.77 and 54.