Dynamic BO bonds-induced viscoelasticity and surface adhesion regulation for constructing konjac glucomannan-based soft actuators with superior mobility and capturability.

In all soft actuators, achieving both outstanding mobility and capturability is crucial; however, these properties are usually mutually exclusive due to the lack of an effective mechanism for controlling the viscoelasticity of the switching polymer matrix while maintaining a moderate surface adhesion. In this study, we propose a dynamic bond cross-linking strategy to successfully develop a magnetically responsive soft hydrogel (MRSH) with exceptional mobility (117.56 mm/s) and capturability.

Interferon Regulatory Factor 4: An Alternative Marker for Plasma Cells in Daratumumab-Treated Patients With Multiple Myeloma.

Introduction: Anti-CD38 therapeutic modalities (e.g., daratumumab) can impede classical CD38 and CD138 gating use for plasma cell (PC) detection in multiple myeloma (MM) patients with minimal residual disease (MRD).

Sulfonated cellulose nanocrystal modified with ammonium salt as reinforcement in poly(lactic acid) composite films.

Poly(lactic acid) (PLA) composites reinforced with cellulose nanocrystals (CNCs) are promising biodegradable materials. However, the poor compatibility and dispersion of CNCs in the PLA matrix remain a significant obstacle to improving the properties of composites. In this study, the modified CNC (CNC-D) was prepared through sulfonation treatment, followed by modification with didecyl dimethyl ammonium chloride (DDAC).

The Application of Morphogo in the Detection of Megakaryocytes from Bone Marrow Digital Images with Convolutional Neural Networks.

The evaluation of megakaryocytes is an important part of the work up on bone marrow smear examination. It has significance in the differential diagnosis, therapeutic efficacy assessment, and predication of prognosis of many hematologic diseases. The process of manual identification of megakaryocytes are tedious and lack of reproducibility; therefore, a reliable method of automated megakaryocytic identification is urgently needed.

The complete genome sequence of a novel mycovirus in the plant-pathogenic fungus Exobasidium gracile.

The plant-pathogenic fungus Exobasidium gracile belongs to the basidiomycetous genus Exobasidium and causes leaf abnormalities in Camellia oleifera. Here, we report a novel mycovirus from E. gracile strain Z-2, called "Exobasidium gracile zybavirus 2" (EgZV2), which is related phylogenetically to a member of the genus Zybavirus in the family Amalgaviridae.

Activity strategy and pattern of the Siberian jerboa () in the Alxa desert region, China.

Rodents exhibit seasonal changes in their activity patterns as an essential survival strategy. We studied the activity patterns and strategies of the Siberian jerboa () in the Alxa desert region to better understand the habitats and behavioural ecology of xeric rodents. We conducted an experiment using three plots to monitor the duration, time, and frequency of the active period of the Siberian jerboa using infrared cameras in the Alxa field workstation, Inner Mongolia, China in 2017.

The effect of grazing on winter survival of midday gerbil () of different genders.

The objective of this study was to investigate the effects of grazing on midday gerbil () population characteristics and survival of animals of different genders. The experiment used a randomized complete block design and was conducted in Alxa Left Banner, Inner Mongolia, China, in 2002 (The agricultural reclamation plots set up in 1994). From April 2006 to October 2010, midday gerbils were live-trapped in 3 light grazing plots, 3 overgrazed plots, and 3 grazing exclusion plots.

Housefly Phormicin inhibits Staphylococcus aureus and MRSA by disrupting biofilm formation and altering gene expression in vitro and in vivo.

The increasing drug resistance of pathogenic bacteria is a crisis that threatens public health. Antimicrobial peptides (AMPs) have been suggested to be potentially effective alternatives to solve this problem. Here, we tested housefly Phormicin-derived peptides for effects on Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA) infections in vitro and in vivo.

Developing and Preliminary Validating an Automatic Cell Classification System for Bone Marrow Smears: a Pilot Study.

Bone marrow smear examination is an indispensable diagnostic tool in the evaluation of hematological diseases, but the process of manual differential count is labor extensive. In this study, we developed an automatic system with integrated scanning hardware and machine learning-based software to perform differential cell count on bone marrow smears to assist diagnosis. The initial development of the artificial neural network was based on 3000 marrow smear samples retrospectively archived from Sir Run Run Shaw Hospital affiliated to Zhejiang University School of Medicine between June 2016 and December 2018.

[Adsorption Properties of Ammonia Nitrogen in Aqueous Solution by Various Materials].

Focusing on the removal of ammonia nitrogen from polluted water, the absorption properties of five materials (zeolite, maifanite, diatomite, bentonite, and activated carbon) were tested. Results showed that the pseudo-second-order kinetic equation was suitable for data fitting for the five materials. The maximum theoretical adsorption capacities of the five materials were 2.

Environmental DNA: An Emerging Tool in Ecological Assessment.

Environmental DNA (eDNA), as a recent research hotspot in environmental science, the use of eDNA in biological monitoring has the advantages of sensitivity and time/labor saving. The eDNA technology combined with scientific advancement has been applied in investigations of target species (such as invasive species, endangered species and other rare species), biomass, and biodiversity. In addition, ecotoxicology studies and environmental pollution impact assessments based on the development of eDNA technology have gradually emerged in recent years.

[Characteristics of Nitrogen and Phosphorus Formation in Atmospheric Deposition in Dianchi Lake and Their Contributions to Lake Loading].

To examine the effects of seasonal changes and precipitation on the concentrations of various nitrogen and phosphorus forms in Dianchi Lake, the concentrations of various nitrogen and phosphorus forms of atmospheric deposition were determined by UV spectrophotometry. Additionally, the contributions of nitrogen and phosphorus to water pollution in Dianchi Lake were discussed. The results showed that the atmospheric depositional nitrogen concentration in Dianchi Lake is generally consistent with the characteristics of the low rainy season and high dry season.

The burrow behavior and influenced factors of a prairie subterranean zokor ().

The Transbaikal zokor () is a dominant rodent distributed in the meadow steppe of Inner Mongolia in northern China. Due to long history of evolution in subterranean environment, the zokor has an adaptive behavior: sealing burrow entrances. When a burrow is damaged, exposed entrances appear, and within a relatively short time, the zokor would be active in sealing the entrances to reduce risks to its survival.

Deriving aquatic life criteria for PBDEs in China and comparison of species sensitivity distribution with TBBPA and HBCD.

Polybrominated diphenyl ethers (PBDEs) are important industrial brominated flame retardants. PBDEs have raised great concerns for their persistence, bioaccumulation, and harm to aquatic life and human health. Pentabromodiphenyl ether (PeBDE), octabromodiphenyl ether (OcBDE), and decabromodiphenyl ether (DeBDE) are three main commercial PBDEs congeners.

[Pollution Characteristics and Health Risk Assessment of Volatile Organic Compounds in Baiyangdian Lake].

In order to survey the present pollution from volatile organic compounds in Baiyangdian Lake, 15 water samples were collected in March 2016, and analyzed for 54 VOCs by purge and trap gas chromatography-mass spectrometry. The distribution characteristics and health risk assessments were investigated, and the pollution from the VOCs was evaluated by a comprehensive pollution index. The survey showed that:① a total of 14 VOCs were detected in Baiyangdian water, with a 100% detection rate for dichloromethane, benzene, toluene, ethylbenzene, xylene, and 1,3,5-trimethylbenzene; xylene had the highest concentration with an average concentration of 564.

[Occurrence and Ecological Risk Assessment of Typical Persistent Organic Pollutants in Baiyangdian Lake].

A comprehensive survey of the pollution characteristics of persistent organic pollutants (POPs) in the surface water and surface sediment of Baiyangdian Lake was carried out. The survey showed that:① The concentrations of the polycyclic aromatic hydrocarbons(PAHs), organic chlorine pesticides (OCPs), and polybrominated diphenyl ethers (PBDEs) in the surface water of Baiyangdian Lake were 71.32-228.

ITRAQ-Based Proteomics Analysis of Triptolide On Human A549 Lung Adenocarcinoma Cells.

Background/aims: Triptolide (TP) is a diterpenoid triepoxide extracted from the traditional Chinese medical herb Tripterygium wilfordii that exerts prominent broad-spectrum anticancer activity to repress proliferation and induce cancer cell apoptosis through various molecular pathways. We previously observed that TP inhibits the progression of A549 cells and pancreatic cancer cells (PNCA-1) in vitro. However, the complex molecular mechanism underlying the anticancer activity of TP is not well understood.

Deriving freshwater safety thresholds for hexabromocyclododecane and comparison of toxicity of brominated flame retardants.

Hexabromocyclododecane (HBCD) is a brominated flame retardant used throughout the world. It has been detected in various environmental media and has been shown toxic to aquatic life. The toxic effects of HBCD to aquatic organisms in Chinese freshwater ecosystems are discussed here.

[Expression of microRNA-221/222 in patients with monoclonal gammopathy of undetermined significance and multiple myeloma].

To detect the expression of miR-221/222 in serum and plasma cells in patients with monoclonal gammopathy of undetermined significance(MGUS) and multiple myeloma(MM), and to explore the possibility of miR-221/222 as biomarkers in the diagnosis and prognosis predicting of MGUS and MM. Bone marrow and serum samples from 14 patients with newly diagnosed MGUS, 81 patients with newly diagnosed or relapsed MM and 10 controls were collected from Sir Run Run Shaw Hospital of Zhejiang University and Tongde Hospital of Zhejiang Province during January 2013 and December 2015. The expressions of miR-221/222 in serum and in sorted CD138 positive plasma cells were detected by qRT-PCR, and the relative expression of miR-221/222 (Δct) was compared between the groups.

Complete mitochondrial genome of Myospalax aspalax (Rodentia, Spalacidae).

False zokor (Myospalax aspalax) is one of the subterranean rodents distributed in East Asia. Molecular data and demography of M. aspalax are unknown, and the population management is difficult, because it is specialized for underground life.