J Clin Lipidol
October 2024
Objective: To determine whether genetic polymorphisms related to pharmacodynamics with metabolic adverse effects, namely leptin promoter () rs7799039, leptin receptor rs1137101, dopamine D2 rs4436578, serotonin 5-HT2A rs6313, and serotonin 5-HT2C rs518147 and rs12836771, are associated with hyperglycemia induced by risperidone or clozapine in adult Thai patients with psychosis.
Methods: A total of 180 patients treated with risperidone-based (=130) or clozapine-based (=50) regimens were included in this study. Blood samples were analyzed for genotyping of the candidate genes and biochemical testing.