[Clinical monitoring in areas of exposure to radiofrequency electromagnetic fields].

Clinical syndromes induced by high intensity radiofrequency electromagnetic field chronic exposure are described. Persons injured by occupational exposure have been observed central nervous system changes in diencephalic syndrome form, cardio-vascular system changes revealed in atherosclerosis, isch(a)emic heart disease and coronary insufficiency rapid progressive expansion. General public living in territory of radar station exposure zone different functional disorders have been identified: vegetative dystonia (asthenovegetative syndrome), thrombocytopenia, decrease of blood coagulation index, and thyroid gland function changes.

[Variability of heart rhythm in patients with vibration disease caused by local vibration].

The authors revealed a dependence of disordered autonomous regulation of cardiac rhythm on vibration disease severity, local vibration and on length of service with exposure to vibration.

[Some aspects of pathogenesis, clinical manifestations and diagnosis of occupational chronic occupational bronchitis].

The article represents data characterizing course of chronic bronchitis in 78 machinery workers subjected to toxic irritative and sensibilizing aerosols. Findings are early bronchial obstruction and pulmonary emphysema, frequent disorders of microcirculation and lesser circle perfusion, propensity to interstitial pulmonary fibrosis and lung hypertension. The results could serve as a base for pathogenetic therapy and necessitate to include COLD into Occupational Diseases Register.

[Method of gunshot liver wound suturing].

A clinical case of using an original staple with the "shape memory" for hemostasis of a hepatic gunshot injury is described. This method gives possibility to remove the syaple out in the postoperative period.

[The pathogenesis, clinical picture and treatment of poisonings by organic solvents, derivatives of chlorinated hydrocarbons (trichloroethylene, carbon tetrachloride)].

Clinical studies and experiments on laboratory animals covered mechanism of trichloroethylene toxicity. The chemical and its metabolites cause nonspecific toxic effects in membranes and therefore induce energy metabolism disorder that is proved to be a trigger of pathologic process in the intoxication. Experimental studies failed to disclose and explain mechanism of compromised calcium metabolism and its role in cardiac manifestations seen in trichloroethylene poisoning.

[Clinico-metabolic effects of fish oil in patients with ischemic heart disease, familial hyperlipoproteinemia and hypertension].

Fifty-five patients with ischemic heart disease, familial hyperlipoproteinemia type IIb and essential hypertension kept anti-atherosclerosis diet incorporating 20 g of ichthyenic oil for 4 weeks. The diet resulted in positive shifts in clinical manifestations, a fall in blood levels of total cholesterol, triglycerides, atherogenic coefficient. The clotting time and duration of hemorrhage proved longer.

[The pathogenesis of trichloroethylene poisoning].

Basing on the results of original clinical and experimental studies, as well as on medical literature data, the contributors proposed a hypothesis of the toxic action of trichloroethylene. It was attempted to prove that the trigger links of trichloroethylene intoxications were the energy exchange disorders caused by the nonspecific membranotoxic actions of the substance's molecules and their metabolites, as well as the extra consumption of energy by the metabolic processing of the poison. Involvement of adaptational reactions, such as the catecholamines' discharge, under the conditions of the damaged metabolic system, decreased the cell's potential and aggravated the severity of intoxications.

[Characteristics of sodium metabolism in rats with experimental hypertension caused by chronic alimentary imbalance].

Beginning from 1.5 month of life Wistar rats were kept under conditions of chronic 1 and 2% salt loading combined with a low-protein diet (6-8% of protein VS, as compared with 23-24% in the normal diet). At the age of 14-16 months when a stable hypertension developed due to the above alimentary imbalance, their sodium metabolism was studied using whole-body radiometry with 22Na.

[The psychological predictors of the participation of hypertension patients in low-sodium diet therapy].

According to the Multifactorial rating scale, the Russian version of Mini-Mult, the Luscher color test and the "Quality of Life" test data the noncompliance patients were characterized by tension, anxiety, irritability, fatigue, low mood, interpersonal relations problems accompanied by the lowering of psychosocial adaptation and quality of life. On the basis of an objective psychological assessment the mathematic formulas for prediction of noncompliance as well as compliance towards hyposodium dietetic therapy have been elaborated.

[Characteristics of water-electrolyte balance in patients with labile essential hypertension and various approaches to the optimal therapy with diuretics and low-sodium diet].

A study of 56 males, aged 22 to 56 years, with uncomplicated essential hypertension, stages IB-IIA, where pretreatment examination was followed by repeat investigation after 4 or 5 weeks of treatment with diuretics or low-sodium diets with strict (less than 2 g), moderate (up to 3 g), or mild (4-4.5 g) restriction of sodium uptake, demonstrated a tendency to sodium retention with fluid redistribution from the interstitium to intravascular space in the presence of diuretic treatment. Where dietary sodium was reduced, extracellular sodium was increased owing to increased residual sodium, while total metabolic sodium dropped, and extracellular fluid increased owing to the increase in interstitial fluid.

[Sodium metabolism in Wistar rats exposed to chronic isotonic salt load after preliminary protein deficiency in the diet according to radiometry of the whole body with 22-Na].

The long-term preliminary protein deficiency in the diet gives rise to irreversible changes in sodium metabolism in experimental animals exposed subsequently to chronic salt load combined with full-value feeding. Apparently such changes do not go, however, beyond the compensatory potentialities of the body exposed to isotonic salt load, since the systolic arterial pressure does not undergo any material changes throughout the whole experiment.

[Characteristics of sodium metabolism in Wistar rats in relation to the uptake of sodium chloride studied by whole body Na-22 radiometry].

The rate of sodium elimination was shown to be inadequate to sodium uptake in rats exposed to prolonged salt loading, the higher the load, the greater the inadequacy. Sodium distribution between vascular and extravascular spaces of the body was also disproportionate in conditions of both excessive and low sodium uptake.

[Modeling of experimental hypertension by chronic salt loading combined with a low-protein diet in Wistar rats].

Combination of chronic salt loading with protein-poor diet produces experimental hypertension with natrium consumption near to physiological. The present model is characterized, compared to the existing one, by stage development, moderate arterial blood pressure elevation and absence of "salt toxicosis" and may be thus considered more adequate for experimental investigation of primary arterial hypertension pathophysiology.

[Clinical variants of the disease caused by exposure to radio-frequency electromagnetic fields].

Clinical data on the characteristics of the course of the disease caused by microwave radiation are presented. It is assumed that the characteristics of the clinical picture of the disease are specified by radiation "geometry".

[Acute occupational poisonings].

The contributors provide an analysis of acute occupational poisoning cases basing on the data obtained by the Institute of Occupational Diseases in Leningrad for 1980-1987, investigate the structure of the registered acute poisonings, their occurrence and reasons. A more detailed clinical description of an acute poisoning with trichlorethylene is given with particular emphasis on its cardiotoxic effects.

[A case of mass legionellosis infection in an enterprise of the rubber technology industry].

On the basis of the analysis of the sanitary and hygienic conditions, epidemiology of a mass disease, clinical picture of the disease during a 6-month trial period the problems of differentiated diagnosis of infectious and toxic processes, examination of capacity for work, the course of diseases were studied in 219 workers who had had legionellosis. The participation of various specialists in the analysis of analogous cases at the enterprises with chemical environmental contamination and developed systems of air conditioning was considered necessary.

[Various immunological aspects of essential and symptomatic hypertension].

131 patients with essential hypertension (EH) and 30 patients with secondary hypertension (SH) of renal genesis were examined, all of them Russian inhabitants of Moscow, aged 20-56. In patients with EH increased rate of HLA-B13 and B22 antigens was determined. The highest rate of HLA-B13 antigen in this group was registered in patients without IHD, while patients with IHD had the highest rate of HLA-B22 antigen compared to controls.

[Effect of physical load and brief monotherapy with obsidan on the characteristics of beta 2-adrenoreceptors of intact lymphocytes in patients with hypertension].

Lymphocytes beta 2-receptor density (LBRD) was studied by binding with 125ICYP in 18 male patients with mild/moderate essential hypertension (EH) before and after propranolol monotherapy. In 5 of these patients LBRD was determined before and after dynamic exercise also. Propranolol therapy evoked different changes in LBRD in patients with EH.

[Body water compartments of patients with chronic heart failure and the refractory edema syndrome].

Using modern methods of investigation body water spaces were studied in 44 persons: 12 healthy ones and 32 patients with various degrees of heart failure. Significant changes in the content and distribution of water with regard to a degree of decompensation were revealed. Dilatation of the volume of extracellular fluid (VEF) was observed in patients with noticeable peripheral edemas as a result of an increase in the volume of circulating plasma (VCP) and an increase in the volume of interstitial fluid (VIF).