α-Synuclein molecular behavior and nigral proteomic profiling distinguish subtypes of Lewy body disorders.

Lewy body disorders (LBD), characterized by the deposition of misfolded α-synuclein (α-Syn), are clinically heterogeneous. Although the distribution of α-Syn correlates with the predominant clinical features, the burden of pathology does not fully explain the observed variability in clinical presentation and rate of disease progression. We hypothesized that this heterogeneity might reflect α-Syn molecular diversity, between both patients and different brain regions.

Non-Dopaminergic Treatments for Motor Control in Parkinson's Disease: An Update.

Glutamatergic, noradrenergic, serotonergic, and cholinergic systems play a critical role in the basal ganglia circuitry. Targeting these non-dopaminergic receptors remains a focus of ongoing research to improve Parkinson's disease (PD) motor symptoms, without the potential side effects of dopamine replacement therapy. This review updates advancements in non-dopaminergic treatments for motor control in PD since 2013.

Etiological profile of noncompressive myelopathies in a tertiary care hospital of Northeast India.

Background: The discovery of antibodies against aquaporin-4 and evolving concepts of noncompressive myelopathies in the 21 century have made a major impact on the etiological profile of these diseases, with few cases turning out to be idiopathic.

Objective: To find causes of noncompressive myelopathy in a tertiary care hospital of Northeast India.

Materials And Methods: An observational study was carried out in the Neurology Department of Gauhati Medical College, Guwahati, from September 2013 to February 2016.