Publications by authors named "Suvi J Parviainen"
Human adipocyte differentiation and composition of disease-relevant lipids are regulated by miR-221-3p.
Biochim Biophys Acta Mol Cell Biol Lipids
January 2021
Article Synopsis
- - MicroRNA-221-3p (miR-221-3p) impacts lipid metabolism and adipocyte differentiation, showing that overexpression inhibits fat storage and key adipogenic genes, while its inhibitor promotes fat accumulation.
- - Global lipid analysis revealed that miR-221-3p overexpression disrupts fat synthesis and alters lipid profiles by increasing ceramides and sphingomyelins while decreasing diacylglycerols.
- - Additionally, high levels of miR-221-3p in breast cancer patients' adipose tissue suggest it may enhance cancer cell growth and invasion, indicating a link between fat metabolism and cancer development.