Publications by authors named "Suvendu Purkait"
Article Synopsis
- The study aimed to investigate the prevalence of autoimmune encephalitis and coexisting viral infections in children with acute encephalitic syndrome (AES).
- It found that out of 867 children examined, 4.2% were diagnosed with autoimmune encephalitis, primarily associated with anti-NMDAR antibodies, while 47.1% had evidence of viral infections, particularly HSV.
- The researchers concluded that autoimmune encephalitis may be more common than previously reported and emphasized the importance of early diagnosis and treatment for better outcomes in affected children.
Autopsy of infants can provide vital information about the cause of death and contributes to the detection of diagnostic errors, especially in a low- or middle-income country. To observe the clinicopathological agreement in neonatal deaths in neonatal intensive care units (NICU) and comment on the additional information retrieved by autopsy. A retrospective observational study was conducted in the NICU from January 2020 to December 2022.
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- * The survey received an 85% response rate from 98 uropathologists, revealing strong agreement on distinguishing between luminal and basal UC types, but varied opinions on the importance of certain genetic tests like FGFR3 and TERT promoter mutations.
- * Most uropathologists acknowledged the aggressive nature of tumors with micropapillary features and favored further evaluation and specific molecular testing for aggressive subtypes, indicating a need for improved consensus in UC classification and treatment strategies.
Article Synopsis
- Pure neuritic leprosy (PNL) is a rare form of leprosy primarily affecting peripheral nerves, with limited large-scale studies on its impact on central nervous system (CNS) functions.
- A prospective observational study assessed nerve conduction studies and evoked potentials in 49 patients with PNL who had positive nerve biopsies, revealing various impairments.
- Findings indicated significant subclinical CNS involvement in a number of PNL patients, suggesting the potential for using these tests (VEP, SSEP, BAEP) for earlier PNL diagnosis despite unclear underlying mechanisms.
Article Synopsis
Diminution of Primary Cilia in the Stromal Cells at the Tumor-stromal Interface Correlates With an Aggressive Tumor Biology in the Urothelial Carcinoma of the Urinary Bladder.
Appl Immunohistochem Mol Morphol
March 2024
Article Synopsis
- Primary cilia (PC) are important cellular structures that help maintain cellular balance and are involved in cancer-related pathways, particularly in urothelial carcinoma (UC) of the bladder.
- This study assessed the presence of PC in the stromal cells at the tumor-stromal interface of UC cases and found that the ratio of primary cilia to nucleus (C:N ratio) significantly decreases from normal to low- and high-grade UC.
- A lower C:N ratio was associated with more aggressive tumor characteristics and a potential correlation with lower recurrence-free survival, indicating that changes in PC may play a role in UC progression.
Giant cell arteritis, or temporal arteritis, is a chronic granulomatous vasculitis that affects large- and medium-sized arteries. An elderly male of 61 years presenting with chronic headaches for the past one year had been misdiagnosed as having migraine because of the similarity in symptoms. General examination revealed the presence of bilateral large, tortuous temporal arteries without any scalp tenderness, diminished arterial pulsations, or skin changes over the dilated arteries.
View Article and Find Full Text PDFExpression of EZH2 and H3K27me3 predicts tumor biology of urothelial carcinoma.
Indian J Pathol Microbiol
November 2023
Article Synopsis
Article Synopsis
Background: MicroRNAs (miRNA) are small non-coding RNAs that regulate the function of mRNA post-transcriptionally in a tissue-specific manner. miRNA expressions are heavily dysregulated in human cancer cells through various mechanisms, including epigenetic changes, karyotype abnormalities, and miRNA biogenesis defects. miRNAs may act as either oncogenes or tumor suppressors under different conditions.
View Article and Find Full Text PDFBackground: Atrophic rhinitis (AtR) is a chronic nasal condition with polygenic and polybacterial etiology. We investigated the clinical outcomes of honey therapy and the associated nasal microbiome in AtR. Methods: For eight weeks, a nonrandomized control trial using a nasal spray of 10% manuka honey and saline on the right and left sides of the nose was conducted on 19 primary AtR patients.
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