Publications by authors named "Suvanto E"
Article Synopsis
- Research shows that women with premature ovarian insufficiency (POI) are significantly more likely to have a history of severe autoimmune diseases, occurring 2.6 times more often than those without POI.
- The study analyzed data from nearly 4,000 women diagnosed with spontaneous POI, comparing their health outcomes to over 15,000 matched controls, which included tracking autoimmune diagnoses from childhood through 2017.
- Findings indicate that women with POI not only had a higher prevalence of autoimmune disorders prior to their diagnosis but also faced a 2 to 3 times increased risk for these diseases for several years afterward.
Background: Establishing local trimester-specific reference intervals for gestational TSH and free T4 (FT4) is often not feasible, necessitating alternative strategies. We aimed to systematically quantify the diagnostic performance of standardized modifications of center-specific nonpregnancy reference intervals as compared to trimester-specific reference intervals.
Methods: We included prospective cohorts participating in the Consortium on Thyroid and Pregnancy.
Article Synopsis
- * The study analyzed data from 65,559 participants across 25 cohorts, focusing on risk factors like maternal age, BMI, and antibody positivity while excluding those with pre-existing thyroid issues.
- * Results indicated a screening rate of 58% among high-risk cohorts, with minimal variation in risk for hypothyroidism based on age and BMI, and TPOAb/TgAb positivity significantly correlated with higher risks for overt and subclinical hypothyroidism.
Introduction: To investigate the occurrence of previous cancer diagnoses in women suffering from premature ovarian insufficiency (POI) and compare it with the general population, shedding light on the association between cancer, cancer treatments, and POI.
Material And Methods: We conducted a nationwide case-control study based on registry data from various sources, including the Social Insurance Institution, Finnish Population Information System, and Finnish Cancer Registry spanning from 1953 to 2018. Our participants comprised all women in Finland who, between 1988 and 2017, received hormone replacement therapy reimbursement for ovarian insufficiency before the age of 40 years (n = 5221).
Article Synopsis
- Triiodothyronine (T3) is important for understanding pregnancy outcomes, but its relationship with adverse obstetric events is not well explored.
- A study examined the effects of gestational free and total T3 levels on issues like preeclampsia and preterm birth using data from over 33,000 mother-child pairs.
- The results revealed complex associations between T3 levels and various risks, indicating that while TT3 may relate to certain outcomes, routine measurements during pregnancy might not significantly improve risk assessment for adverse outcomes.
Article Synopsis
- Guidelines recommend using specific thyroid hormone reference intervals during pregnancy, but these are often not available, leading to alternative diagnostic methods.
- A study analyzed data from over 52,000 women and found that these alternative methods had low sensitivity (0.63-0.82) and high false discovery rates (0.11-0.35) compared to trimester-specific reference intervals.
- The results indicate that using alternative approaches for thyroid hormone testing in pregnancy can result in significant misdiagnosis, highlighting the need for better strategies for detecting thyroid dysfunction in pregnant women.
The fetus is fully dependent on maternal thyroid hormones until mid-gestation and suboptimal maternal thyroid function has been associated with alterations in the neurodevelopment of the offspring. We used maternal free thyroxine (fT4) and thyrotropin (TSH) levels in early gestation to study the association of maternal thyroid function during early pregnancy and offspring brain white matter (WM) integrity in early adulthood. Our study population consisted of a total of 292 mother-child pairs.
View Article and Find Full Text PDFStudy Question: Are genetic disorders and congenital malformations associated with premature ovarian insufficiency (POI)?
Summary Answer: A wide range of genetic disorder and congenital malformation diagnoses are associated with POI, especially early onset POI.
What Is Known Already: POI is known to be associated with some genetic disorders, such as Turner syndrome and Fragile X premutation. Multiple genetic syndromes, such as ataxia teleangiectasia and galactosemia, have also been associated with an increased risk of POI, and many of these genetic syndromes manifest with various congenital malformations.
Objective: Increasing age and menopausal transition increase the risk of sexual dysfunction. Sexual dysfunction is common in women experiencing menopause before the age of 40 years, whereas evidence on sexual function in women experiencing menopause in their mid-40s is scarce. We aimed to investigate sexual function in 46-year-old women in relation to their menopausal status.
View Article and Find Full Text PDFContext: Interpretation of thyroid function tests during pregnancy is limited by the generalizability of reference intervals between cohorts due to inconsistent methodology.
Objective: (1) To provide an overview of published reference intervals for thyrotropin (TSH) and free thyroxine (FT4) in pregnancy, (2) to assess the consequences of common methodological between-study differences by combining raw data from different cohorts.
Methods: (1) Ovid MEDLINE, EMBASE, and Web of Science were searched until December 12, 2021.
Introduction: Thyroid diseases in pregnancy are relatively common and are associated with adverse pregnancy and perinatal outcomes, increasing a neonate's risk of admission to the neonatal intensive care unit (NICU). The aim of this study was to evaluate the indications for increased risk of NICU admission among the neonates of hypothyroid and hyperthyroid mothers.
Material And Methods: The study data consisted of all singleton deliveries (n = 734 773) between 2004 and 2016 in Finland collected from the Finnish Medical Birth Register.
Article Synopsis
- This study investigates the impact of thyroid autoimmunity, specifically TPO antibodies (TPOAbs) and thyroglobulin antibodies (TgAbs), on thyroid function in pregnant women, analyzing data from 20 cohorts with a total of 51,138 participants.
- The findings show that isolated positivity for TPOAbs and TgAbs is relatively common, with some participants testing positive for both; women with these antibodies generally had higher TSH levels compared to those without antibodies.
- A dose-response relationship indicates that increased levels of TPOAbs and TgAbs correlate with higher TSH levels, but only TPOAbs maintained a significant relationship when adjusting for the presence of TgAbs, also linking
Objective: To investigate whether an earlier-onset climacteric phase is associated with autonomic imbalance at the age of 46 years.
Methods: This cross-sectional birth cohort study included 2661 women aged 46 years. Participants were divided into climacteric ( = 359) and preclimacteric ( = 2302) groups based on menstrual history and follicle stimulating hormone values.
Article Synopsis
- Adequate maternal thyroid function is crucial for a healthy pregnancy, yet previous studies on thyroid dysfunction and pregnancy-related hypertension show inconsistent and varied results.
- In this systematic review and meta-analysis, researchers analyzed data from multiple cohort studies to investigate the link between thyroid function abnormalities and risks of gestational hypertension and pre-eclampsia.
- The study included a large sample of 46,528 pregnant women, focusing on thyroid-stimulating hormone, free thyroxine levels, and thyroid antibodies, while excluding certain groups to ensure the accuracy of the findings.
Study Question: What is the incidence of premature ovarian insufficiency (POI), has the incidence of POI changed over time, and what is the risk of POI among relatives of POI women?
Summary Answer: The incidence of POI increased among females aged 15-19 years from 2007 onwards and decreased in older age groups, and among relatives of women with POI the risk of POI is significantly increased.
What Is Known Already: So far, there has been no good quality, nationwide studies of the incidence of POI. Early menopause has been associated with the elevated risk of early menopause among relatives, but the knowledge of the familial risk of POI is scarce.
Prior research suggests that severe iodine deficiency in pregnancy may be associated with stillbirth. However, the relationship between mild to moderate iodine insufficiency, which is prevalent even in developed countries, and risk of stillbirth is unclear. We thus examined associations of iodine status and risk of stillbirth in a prospective population-based nested case-control study in Finland, a mild to moderately iodine insufficient population.
View Article and Find Full Text PDFObjective: Thyroid dysfunction affects up to 5-7% of all pregnancies. The rates of thyroid hormone use in nonpregnant population have substantially increased in recent years. The aim of this study was to assess possible changes in the use of levothyroxine substitution and antithyroid drugs over time in pregnant women.
View Article and Find Full Text PDFObjective: We investigated whether more advanced climacteric stage in the mid-40s is associated with thyroid autoimmunity and dysfunction.
Methods: This cross-sectional cohort study included 2,569 46-year-old women. Thyroid hormone, thyroid peroxidase antibodies, and follicle-stimulating hormone levels were determined.
Objective: To investigate vitamin D status in women with the onset of the climacteric phase by age 46 as both early menopause and inadequate vitamin D status may increase the risk of adverse health outcomes.
Methods: A cross-sectional study included 2,544, 46-year-old women from a birth cohort. Women were divided into the following two groups according to their menstrual history and follicle-stimulating hormone (FSH) concentration: 1) climacteric (FSH ≥25 IU/L and amenorrhea ≥4 mo, n = 351) and 2) preclimacteric women (FSH <25 IU/L and having regular/irregular menstrual cycles, n = 2,193).
Objective: To investigate whether the early-onset menopausal transition is associated with deteriorated glucose tolerance in women in their mid-forties.
Methods: A cross-sectional analysis of a cohort study including 2,632 women of the Northern Finland Birth Cohort 1966. The participants were divided into two groups by their menstrual history and follicle-stimulating hormone values at age 46: climacteric and preclimacteric women.
Preeclampsia, a pregnancy disorder that includes hypertension and proteinuria, is a major cause of maternal and fetal morbidity and mortality. Some studies, but not all, have found that women with preeclampsia have significantly lower iodine levels than healthy pregnant women. Resolving this issue is important because iodine deficiency in pregnancy is common in the USA and parts of Europe including Finland.
View Article and Find Full Text PDFArticle Synopsis
- The study explored the effects of maternal hyperthyroidism and the use of antithyroid drugs (ATDs) on pregnancy outcomes in Finland from 2004 to 2013, involving over 571,000 singleton births.
- Out of 2,144 hyperthyroid women identified, 580 used ATDs, and findings indicate these mothers were at higher risk for complications like gestational hypertension, cesarean sections, and preterm births compared to mothers without thyroid issues.
- The research concludes that women with hyperthyroidism or a history of the condition should be closely monitored during pregnancy due to the elevated risks of complications for both mothers and newborns.
Background: Adequate transplacental passage of maternal thyroid hormone is important for normal fetal growth and development. Maternal overt hypothyroidism and hyperthyroidism are associated with low birthweight, but important knowledge gaps remain regarding the effect of subclinical thyroid function test abnormalities on birthweight-both in general and during the late second and third trimester of pregnancy. The aim of this study was to examine associations of maternal thyroid function with birthweight.
View Article and Find Full Text PDFNormal maternal thyroid function during pregnancy is essential for fetal development and depends upon an adequate supply of iodine. Little is known about how iodine status is associated with preterm birth and small for gestational age (SGA) in mildly iodine insufficient populations. Our objective was to evaluate associations of early pregnancy serum iodine, thyroglobulin (Tg), and thyroid-stimulating hormone (TSH) with odds of preterm birth and SGA in a prospective, population-based, nested case-control study from all births in Finland (2012-2013).
View Article and Find Full Text PDFImportance: Maternal hypothyroidism and hyperthyroidism are risk factors for preterm birth. Milder thyroid function test abnormalities and thyroid autoimmunity are more prevalent, but it remains controversial if these are associated with preterm birth.
Objective: To study if maternal thyroid function test abnormalities and thyroid autoimmunity are risk factors for preterm birth.