Bistability regulates TNFR2-mediated survival and death of T-regulatory cells.

A subgroup of T cells called T-regulatory cells (Tregs) regulates the body's immune responses to maintain homeostasis and self-tolerance. Tregs are crucial for preventing illnesses like cancer and autoimmunity. However, contrasting patterns of Treg frequency are observed in different autoimmune diseases.

Understanding noise in cell signalling in the prospect of drug-targets.

The introduction of noise to signals can alter central regulatory switches of cellular processes leading to diseases. Noise is inherently present in the cellular signalling system and plays a decisive role in the input-output (I/O) relation. The current study aims to understand the noise tolerance of motif structures in the cell signalling processes.

Effect of COVID-19-induced lockdown on NO pollution using TROPOMI and ground-based CPCB observations in Delhi NCR, India.

The present study investigates the reduction in nitrogen dioxide (NO) levels using satellite-based (Sentinel-5P TROPOMI) and ground-based (Central Pollution Control Board) observations of 2020. The lockdown duration, monthly, seasonal and annual changes in NO were assessed comparing the similar time period in 2019. The study also examines the role of atmospheric parameters like wind speed, air temperature, relative humidity, solar radiation and atmospheric pressure in altering the monthly and annual values of the pollutant.

Bistability in cell signalling and its significance in identifying potential drug-targets.

Motivation: Bistability is one of the salient dynamical features in various all-or-none kinds of decision-making processes. The presence of bistability in a cell signalling network plays a key role in input-output (I/O) relation. Our study is aiming to capture and emphasize the role of motif structure influencing the I/O relation between two nodes in the context of bistability.