Susceptibility of nucleotide-binding oligomerization domain 2 mutations to Whipple's disease.

Objectives: Whipple's disease (WD) results from infection of the bacteria Tropheryma whipplei (TW). This disease is characterized by macrophage infiltration of intestinal mucosa and primarily affects Caucasian males. Genetic studies of host susceptibility are scarce.

Cryptogenic Liver Abscess Caused by a K1 Serotype Isolate.

Hypervirulent (hv) is a common cause of pyogenic liver abscesses in Asia but is quite uncommon in North America. Among the cases described in North America, only occasional reports have described molecular strain typing to confirm the K1 strain as the causative agent. We report a 56-year-old Hispanic female with no previous intra-abdominal pathology and no recent travel, who presented with subacute abdominal pain and developed bacteremia and monomicrobial pyogenic liver abscess due to a community-acquired K1 serotype isolate.

and Mechanisms of Antifungal Resistance.

can be present as a cutaneous, mucosal or deep-seated organ infection, which is caused by more than 20 types of sp., with being the most common. These are pathogenic yeast and are usually present in the normal microbiome.

Aspergillus osteomyelitis: review of 12 cases identified by the Prospective Antifungal Therapy Alliance registry.

A review of 12 patients with proven Aspergillus osteomyelitis was undertaken between July 2004 and October 2007. Aspergillus fumigatus was most commonly identified (n = 9). Voriconazole was commonly administered (11/12; 91.

Mycobacterium avium-avium-associated typhlitis mimicking appendicitis in an immunocompetent host.

Mycobacterium avium-intracellulare complex (MAC) primarily causes respiratory infection in patients with underlying lung disease or disseminated disease in immunocompromised patients. We report a unique case of MAC disease in the terminal ileum of a healthy patient, mimicking appendicitis. This case emphasizes the need to further explore MAC pathogenesis in immunocompetent hosts.

Hyposplenism: a comprehensive review. Part II: clinical manifestations, diagnosis, and management.

In the first part of this review, we described the physiological basis of splenic function and hypofunction. We also described the wide spectrum of diseases that can result in functional hyposplenism. In the second part of this review, we will be discussing the clinical picture, including complications, diagnostic methods, and management of hyposplenism.