Publications by authors named "Sutandyo N"
Background And Aim: Non-small cell lung cancer (NSCLC) is the most common lung cancer found in elderly patients. Aging and chronic inflammation are related to its pathogenesis. Functional status, lymphocyte-to-monocyte ratio and platelet-to-lymphocyte ratio describe a chronic inflammation and correlate to the survival of older adults with advanced-stage (IIIB-IV) NSCLC.
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- Cytogenetics plays a critical role in diagnosing and predicting outcomes for myelodysplastic syndrome (MDS), with specific profiles indicating a higher risk of progression to acute myeloid leukemia (AML).
- This study focused on Indonesian patients with MDS, assessing their cytogenetic profiles through clinical examinations and follow-ups over one year.
- Key findings included the identification of monosomy 7 and chromosome 5 deletions in certain patients, along with a notable risk of AML transformation in those with MDS-EB.
Article Synopsis
- Breast cancer is a significant health issue in Indonesia, prompting a study to explore potential biomarkers, specifically mitochondrial DNA copy number (mtDNA-CN) and relative telomere length (RTL), which are linked to oxidative stress.
- Researchers conducted a case-control study comparing blood samples from 175 breast cancer patients to 181 healthy individuals, utilizing quantitative real-time PCR for analysis.
- Results showed that younger breast cancer patients (under 48) had higher mtDNA-CN and RTL compared to healthy individuals, indicating these biomarkers might be useful for early breast cancer risk assessment.
Objective: This study aimed to investigate the associations of CD8+, PARP, and EGFR expressions with two-year survival in patients with triple-negative breast cancer (TNBC).
Methods: A retrospective cohort study was conducted in a national cancer center. All patients aged 18 years diagnosed with TNBC (2013-2017) were included and followed for 24 months or until the patients were deceased.
Background: Triple-negative breast cancer (TNBC) has been documented as the most aggressive subtype of breast cancer. This study aimed to analyze antitumor and protumor immune activities, and their ratios as significant prognostic biomarkers in metastatic TNBC (mTNBC).
Methods: A multicenter cohort study was conducted among 103 de novo mTNBC patients.
Article Synopsis
- Advances in molecular biology and high-throughput tests are enhancing lung cancer management by identifying genetic variations in patients.* -
- A study analyzing 627 tissue samples and 80 liquid biopsy samples from lung cancer patients revealed various EGFR variants using RT-PCR and next-generation sequencing (NGS).* -
- The results indicated that EGFR variants are prevalent, and liquid biopsy with ctDNA can uncover a wider range of genetic variations, which is crucial for tailoring treatment plans.*
Article Synopsis
- Despite advancements in lung cancer treatment, many cases are diagnosed late, and biomarkers like microRNA10b (miR-10b), suPAR, and PAI-1 show potential for assessing disease progression and treatment response in advanced non-small cell lung cancer (NSCLC).
- A study involving 40 advanced stage NSCLC patients revealed that high levels of miR-10b may be protective against disease progression, while elevated suPAR levels served as a risk factor for worse outcomes, and increased PAI-1 levels indicated a protective effect against poor treatment response.
- Ultimately, the results highlighted suPAR as a significant independent risk factor for the progression and poor response in NSCLC, while miR-10b was not reliable
Article Synopsis
- - The high mortality rate in breast cancer patients is often linked to metastases that resist systemic therapies, with circulating miRNAs-221 and miR-222 identified as key factors in this resistance by promoting cancer cell growth and survival.
- - A study involving luminal subtype breast cancer patients treated with tamoxifen found that miR-221 levels significantly differed between patients with local recurrence and those without, indicating its potential role in predicting tamoxifen resistance.
- - The findings suggest that measuring circulating miR-221/222 could help identify breast cancer patients at risk for treatment failure with tamoxifen, enabling earlier intervention and more effective treatment strategies.
Article Synopsis
- Metastatic breast cancer is linked to high levels of morbidity and mortality, with a focus on how insulin resistance might impact its occurrence.
- The study analyzed data from 150 breast cancer patients to examine the relationship between insulin resistance, measured by HOMA-IR and TyG Index, and the incidence of metastatic cancer.
- Results indicated no significant correlation between insulin resistance metrics and the incidence of metastatic breast cancer, suggesting that insulin resistance may not be a contributing factor.
Introduction: Cachexia is prevalent in cancer and is associated with poorer prognosis. We aimed to investigate the association of interleukin-6 (IL-6) and vitamin D levels with cachexia in cancer patients. We also assessed the relationship between body composition profile and cachexia, IL-6, and vitamin D levels.
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- Most patients with advanced non-small cell lung cancer (NSCLC) have a poor survival rate, and the study investigates how nutritional status impacts treatment response and overall survival in these patients.
- The study followed 174 patients with stage II-IV NSCLC over two years, revealing that only a small percentage achieved a complete response to treatment, and the median survival was 12 months.
- Findings indicated that being male and overweight or obese are linked to lower survival rates, regardless of other factors like age, disease stage, and baseline health.
Article Synopsis
- The study investigates how pretreatment nutritional status, HPV infection, and tumor-infiltrating lymphocytes affect outcomes in head and neck squamous cell carcinoma (HNSCC) patients in Indonesia.
- Data from 30 patients who underwent chemotherapy revealed that underweight individuals had a significantly higher risk of progressive disease and shorter survival times compared to those with normal or higher BMI.
- The findings suggest that being underweight negatively impacts survival in HNSCC, while HPV infection and TIL levels do not appear to influence treatment response or overall survival.
Article Synopsis
- The study investigates how cultural and religious beliefs influence the attitudes of Indonesian cancer patients and their family caregivers towards advance care planning, specifically focusing on their experiences with medical information and decision-making.
- Researchers conducted semi-structured interviews with 16 cancer patients and 15 caregivers in Jakarta and Yogyakarta, utilizing thematic analysis to identify key themes.
- Key findings highlight that participants value sensitive communication about bad news, may see decision-making as a right or responsibility, and face challenges with future planning due to cultural and religious perspectives.
Article Synopsis
- - Lung cancer is a leading cause of cancer-related deaths among men, necessitating a biological marker for better treatment outcomes in non-small cell lung cancer (NSCLC) patients, particularly in Indonesia.
- - A retrospective cohort study analyzed various blood test results (e.g., hemoglobin, leukocytes, tumor markers) to assess their impact on the survival rate of NSCLC patients.
- - Significant findings indicated that poor prognostic factors include advanced performance status, late TNM stage, high white blood cell counts, low platelets, and other lab abnormalities, with the need for more research on their correlatives.
Article Synopsis
- Anemia is a prevalent blood disorder in older adults, particularly in Indonesia, where a lack of studies has left a gap in understanding its impact on muscle strength in this demographic.
- The study aims to assess anemia prevalence among Indonesian elderly citizens aged 60 and older and explore its relationship with handgrip strength using data from a large sample size from the Indonesian Family Life Survey-5 (IFLS-5).
- Findings reveal that 38.8% of analyzed individuals have anemia, with a significant increase in prevalence among those aged 80 and above, and indicates a positive correlation between lower hemoglobin levels and decreased handgrip strength.
Article Synopsis
- This study investigates the perspectives of Indonesian healthcare professionals on advance care planning for cancer patients, focusing on a middle-income country with strong family and religious ties.
- Conducted through focus-group discussions, the research identified four key elements important for advance care planning: the family's role in decision-making, communication norms, religious beliefs about life, and the need for a structured support system.
- Participants concluded that respecting cultural values and religious beliefs is crucial for effective advance care planning in Indonesia, as these factors can both complicate and enhance patient and family engagement.
Article Synopsis
- The study aimed to systematically review and analyze the risk of acute myeloid leukemia (AML) transformation in adult patients with myelodysplastic syndrome (MDS), focusing on specific gene mutations.
- A comprehensive literature search identified 14 relevant articles, revealing that mutations in the SRSF2, DNMT3A, IDH, and RUNX1 genes were linked to an increased risk of AML transformation in these patients.
- The findings suggest that while some mutations (like U2AF1) do not significantly affect transformation risk, others notably increase the likelihood, indicating the importance of genetic profiling in MDS management.
Article Synopsis
- - Approximately 70% of breast cancers are estrogen receptor-α (ERα)-positive, and tamoxifen, a selective ER modulator, is commonly used in treatment, but resistance to it can occur, often involving microRNAs like miR-221.
- - A study compared breast cancer patients with and without local or metastatic recurrence after at least one year of tamoxifen therapy, focusing on the expression levels of miR-221.
- - Results showed significantly higher expression of miR-221 in tamoxifen-resistant cases, suggesting that miR-221 may serve as a potential biomarker for predicting resistance to tamoxifen treatment in breast cancer patients.
Article Synopsis
- The study aimed to assess the impact of leukapheresis on early mortality in adults with acute myeloid leukemia (AML) and hyperleukocytosis, as previous findings were inconclusive.
- Researchers conducted a systematic review up to October 2021, analyzing data from various medical databases and focusing on studies comparing early mortality in patients treated with leukapheresis versus those who were not.
- Results from eleven eligible studies indicated no significant difference in early mortality between the two groups, suggesting that leukapheresis does not improve early outcomes for these patients.
Article Synopsis
- This study investigates the link between the triglyceride-glucose (TyG) index and breast cancer risk among individuals aged 19 and older in Indonesia, using a case-control design.
- The findings showed that the TyG index was significantly higher in breast cancer patients compared to controls, with higher quartiles of the TyG index indicating increased odds of developing breast cancer.
- The study concluded that a higher TyG index is associated with breast cancer risk in a nonlinear manner, along with other factors like smoking and contraceptive use.
Article Synopsis
- Iron overload is a significant issue in thalassemia patients, particularly those dependent on blood transfusions, which can exacerbate oxidative stress as measured by malondialdehyde (MDA) levels.* -
- A study involving 63 adult patients analyzed MDA levels before and after blood transfusions and found no significant change or correlation between MDA and iron overload markers like serum ferritin (SF) or transferrin saturation (TS).* -
- The results suggest that, despite blood transfusions increasing iron levels in thalassemia patients, there is no corresponding rise in oxidative stress as indicated by MDA levels.*
Article Synopsis
- This study investigates the potential of the FIB-4 index as a predictor of mortality in patients with both hematological malignancies and COVID-19, focusing on finding an optimal cut-off value.
- Conducted at Dharmais National Cancer Hospital in Indonesia, it analyzed 70 patients and found a significant correlation between higher FIB-4 values and increased mortality risk over a 3-month period.
- The results indicated that a FIB-4 index greater than 3.85 had strong predictive power for mortality, with implications for patient management and treatment decisions.
Objective: This study aimed to compare the mortality rate between advanced-stage non-small cell lung cancer patients (NSCLC) with and without COVID-19. This study also explores the possible laboratory characteristics used for prognostication in patients with NSCLC and COVID-19. Additionally, this study evaluated potential differences in laboratory values between the case and control groups.
View Article and Find Full Text PDFThe role of microRNA in cancer cachexia and muscle wasting: A review article.
Caspian J Intern Med
March 2021
Article Synopsis
- * Micro ribonucleic acid (miRNA) plays a significant role in cachexia by regulating proteins and influencing inflammatory pathways.
- * Understanding miRNA's role could pave the way for new treatments targeting cancer cachexia, improving patient outcomes.
Article Synopsis
- The study investigates the effects of melatonin on patients with locally advanced oral squamous cell carcinoma (OSCC) undergoing neoadjuvant chemotherapy, focusing on its impact on miR-210 and CD44 expression, which are related to tumor resistance and hypoxia.
- Results showed that melatonin administration led to a decrease in miR-210 and CD44 levels, as well as a reduction in the percentage of residual tumor, but these changes were not statistically significant.
- The conclusion suggests that while adding melatonin to chemotherapy may reduce certain tumor markers and tumor residue in OSCC patients, the effects were not significant enough to draw definitive conclusions.