Multi-scale analysis of segmental outflow patterns in human trabecular meshwork with changing intraocular pressure.

Purpose: Aqueous humor filtration in the trabecular meshwork is believed to be non-uniform or "segmental" such that only a fraction of trabecular meshwork is filtration-active at any given instant. The goal was to quantify the filtration-active fraction of human trabecular meshwork and to determine how filtration patterns change with outflow facility and intraocular pressure (IOP).

Methods: Six pair of enucleated human eyes were perfused with fluorescent tracer microspheres (0.