Retinal perfusion changes in radiation retinopathy.

Purpose: To investigate retinal blood flow and oxygen saturation changes in patients diagnosed with retinopathy following plaque radiation treatment to treat choroidal melanoma.

Methods: Eight patients (mean age 55.75 years, SD 12.

Preliminary investigation of multispectral retinal tissue oximetry mapping using a hyperspectral retinal camera.

Oximetry measurement of principal retinal vessels represents a first step towards understanding retinal metabolism, but the technique could be significantly enhanced by spectral imaging of the fundus outside of main vessels. In this study, a recently developed Hyperspectral Retinal Camera was used to measure relative oximetric (SatO2) and total hemoglobin (HbT) maps of the retina, outside of large vessels, in healthy volunteers at baseline (N = 7) and during systemic hypoxia (N = 11), as well as in patients with glaucoma (N = 2). Images of the retina, on a field of view of ∼30°, were acquired between 500 and 600 nm with 2 and 5 nm steps, in under 3 s.

Intervisit Repeatability of Retinal Blood Oximetry and Total Retinal Blood Flow Under Varying Systemic Blood Gas Oxygen Saturations.

Purpose: The aim of the study is to validate and calibrate the Doppler spectral-domain optical coherence tomography (SD-OCT) derived total retinal blood flow (TRBF) and metabolic hyperspectral retinal camera (MHRC) derived oxygen saturation (SO2) of major retinal vessels in human volunteers using a novel and exact provocation technique (RespirAct) that allows the precise control of the end-tidal partial pressure of oxygen (PETO2). Between visit repeatability of the TRBF and retinal blood SO2 also were studied.

Methods: One eye of 11 young healthy subjects was chosen randomly for the study.

Change in vision after retinal pigment epithelium tear following the use of anti-VEGF therapy for age-related macular degeneration.

Purpose: We investigated visual acuity outcomes and their associations in the setting of retinal pigment epithelium tear (RPET) following the use of anti-vascular endothelial growth factor (anti-VEGF) agents.

Methods: This retrospective review included all patients treated for neovascular age-related macular degeneration (AMD) with an anti-VEGF agent who subsequently developed an RPET. All patients who developed an RPET were identified and outcome measures data were recorded and analysed.

Cerebral oxygen saturation: graded response to carbon dioxide with isoxia and graded response to oxygen with isocapnia.

Background: Monitoring cerebral saturation is increasingly seen as an aid to management of patients in the operating room and in neurocritical care. How best to manipulate cerebral saturation is not fully known. We examined cerebral saturation with graded changes in carbon dioxide tension while isoxic and with graded changes in oxygen tension while isocapnic.