Publications by authors named "Susital Mal"
Article Synopsis
- The study presents a method for synthesizing 5-bromouracil derivatives using visible light, N-bromosuccinimide, and acetonitrile, demonstrating effective results with multiple uracil derivatives.
- The reaction uses a radical pathway and electrophilic substitution to enhance speed, successfully producing twenty-one different derivatives characterized by spectroscopic methods.
- The researchers showcased the scalability of the process with a looping falling film reactor, achieving efficient production from milligrams to 1.2 kg per day while maintaining consistent photonic characteristics.
Herein, we describe the design and synthesis of a series of C-5-substituted diazenyl derivatives of uracil, exhibiting selective and potent antileishmanial but not antibacterial or antifungal activity. The formation of the substituted derivatives was confirmed by using FTIR, H, C NMR, and HRMS analysis. Among all of the sets of tested compounds, only three [, and ] showed the highest activity against (LD) promastigote and amastigote models of LD infections.
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