Evaluation of the long-term antibiofilm effect of a surface coating with dual functionality of antibacterial and protein-repellent effects.

The provision of antibacterial properties to resinous restorative/reconstructive materials by incorporating polymerizable bactericides such as 12-methacryloyloxydodecylpyridinium bromide (MDPB) has been attempted. Previously, MDPB was combined with 2-methacryloyloxyethyl phosphorylcholine (MPC) to fabricate a copolymer coating to increase antibacterial effectiveness by protein repelling. In this study, we assessed the longevity of the protein-repelling, antibacterial, and antibiofilm effects of the MDPB-MPC copolymer.

Development of novel surface coating composed of MDPB and MPC with dual functionality of antibacterial activity and protein repellency.

Resin-based reconstructive/restorative materials with antibacterial effects are potentially useful for preventing dental and oral diseases. To this end, the immobilization of an antibacterial component on the surface of a resin by incorporating polymerizable bactericide such as a quaternary ammonium compound-monomer 12-methacryloyloxydodecylpyridinium bromide (MDPB) is an effective technique. However, the effectiveness of immobilized bactericide is reduced by salivary protein coverage.

Thermally Assisted Generation of Protein-Poly(ethylene sodium phosphate) Conjugates with High Mineral Affinity.

Protein therapeutics has recently attracted interest in various medical treatments. However, the structure and function preservation in proteins under physiological conditions is still an important issue and reliable immobilization techniques are required. In this study, the thermally assisted complexation of proteins with amphiphilic polyphosphoesters is proposed as a new methodology for their durability improvement.

Cascade post-polymerization modification of single pentafluorophenyl ester-bearing homopolymer as a facile route to redox-responsive nanogels.

Poly(pentafluorophenyl methacrylate) (PPFPMA) was first subjected to post-polymerization modification with oligo(ethylene glycol) methyl ether amine (OEG-NH) and yielded poly(pentafluorophenyl methacrylate)-co-poly(oligo(ethylene glycol methacrylamide)), PPFPMA-co-POEGMAM. These amphiphilic random copolymers can self-assemble into micellar nanoparticles in water having sizes less than 100nm. By tandemly reacting the pentafluorophenyl (PFP) groups in the copolymeric nanoparticles with a dithiol crosslinker, cystamine, redox-responsive nanogels can be formed.