Publications by authors named "Susila Hadiyati"
Article Synopsis
- Methane-utilizing methanotrophs, like Methylomonas sp. DH-1 from brewery sludge, are being explored for their potential in industrial bio-catalysis, particularly for converting methane into useful chemicals.
- The researchers genetically modified Methylomonas sp. DH-1 to enhance succinate production by altering the TCA cycle and removing certain enzymes, leading to a significant increase in succinate yield—up to 10 times greater than the original strain.
- The best performing mutant strain (DS-GL) produced around 195 mg/L of succinate in a fed-batch bioreactor, demonstrating a novel method for effectively converting methane to succinate.
Methane is considered a next-generation feedstock, and methanotrophic cell-based biorefinery is attractive for production of a variety of high-value compounds from methane. In this work, we have metabolically engineered Methylomicrobium alcaliphilum 20Z for 2,3-butanediol (2,3-BDO) production from methane. The engineered strain 20Z/pBudK.
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