Publications by authors named "Susie S Mikkelsen"
A new disease in farmed rainbow trout (Onchorhyncus mykiss) was described in Norway in 2013. The disease mainly affected the heart and resembled heart and skeletal muscle inflammation (HSMI) in Atlantic salmon (Salmo salar L.).
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- The rainbow trout is a valuable aquaculture species in Europe, but its production faces threats from the highly lethal viral hemorrhagic septicemia (VHS) disease caused by the VHS virus (VHSV), specifically subgenogroup Ia.
- A comprehensive study analyzed 651 complete G gene sequences from 11 European countries (1971-2015), revealing the extensive spread and mixing of VHS Ia isolates, likely due to the trout trade.
- Researchers found nine distinct Ia clades, rapid population growth events, and a high mutation rate of the virus, with significant differences in VHS handling and effects observed between Germany and Denmark.
The innate immune system provides an initial defense system against microbial infections and contributes to the development of adaptive immune response. Type I interferons play a pivotal role for the first line of defense against virus infections, and dendritic cells (DCs) are important sensors of pathogens responsible for priming of adaptive immune responses in lymphoid organs. Here we have investigated the role and mechanisms of activation of the MAPK pathway in innate immune responses induced by Sendai virus, a negative sense single-stranded RNA virus.
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