Publications by authors named "Susie Gaillot"
Article Synopsis
- Researchers identified a new strain of bacteria in France called 13A297, part of the ST25 clone, which shows high resistance to β-lactam antibiotics, including cefiderocol.
- Whole genome sequencing revealed a large plasmid carrying resistance genes, and when introduced into other bacterial strains, significantly increased their cefiderocol resistance.
- Studies showed that a specific change in the NDM-9 enzyme improves its binding and efficiency against cefiderocol, underscoring the importance of residue 152 for antibiotic resistance.
Cefiderocol is a siderophore-conjugated cephalosporin with potent activity against multidrug-resistant Gram-negative pathogens including . The aim of this study was to evaluate cefiderocol testing methods on a relevant collection of 97 spp. isolates.
View Article and Find Full Text PDFExposure of to Cinnamaldehyde Selects Multidrug Resistant Mutants.
Antibiotics (Basel)
December 2022
Cinnamaldehyde (CNA), the main component of cinnamon essential oil, is one of the most active plant compounds against nosocomial pathogen . Exposure of wild-type strain PA14 (MIC 700 µg/mL) for 5 to 10 days to fixed (900 µg/mL) or increasing (from 900 to 1400 µg/mL) concentrations of this natural antibacterial resulted in emergence of resistant mutants CNA-A1 to A3, and CNA-B1 to B7, respectively. Genome sequencing experiments showed that each of CNA-A1 to A3 mutants differed from PA14 by one SNP, and a slight increase in CNA resistance level (from 700 to 900 µg/mL).
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