Alkyl and Aryl Derivatives Based on -Coumaric Acid Modification and Inhibitory Action against and .

In low-income populations, neglected diseases are the principal cause of mortality. Of these, leishmaniasis and malaria, being parasitic, protozoan infections, affect millions of people worldwide and are creating a public health problem. The present work evaluates the leishmanicidal and antiplasmodial action of a series of twelve -coumaric acid derivatives.

Trypanocidal Mechanism of Action and Studies of -Coumaric Acid Derivatives.

species are responsible for chronic and systemic infections in millions of people around the world, compromising life quality, and family and government budgets. This group of diseases is classified as neglected and causes thousands of deaths each year. In the present study, the trypanocidal effect of a set of 12 ester derivatives of the -coumaric acid was tested.