Publications by authors named "Sushmitha Arumugam"
J Neuroinflammation
January 2022
Article Synopsis
- Toxoplasma gondii is a parasite that can invade the central nervous system by crossing biological barriers, with previous studies focusing mainly on the blood-brain barrier (BBB), but this study investigates the role of the choroid plexus (CP) as well.*
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- The research includes methods such as analyzing the CP and brain microvessels for parasite burden, studying immune response activation, and assessing changes in tight junctions and barrier permeability due to the infection.*
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- Findings indicate that T. gondii initially infects endothelial cells in the CP, triggering an early immune response and causing damage to tight junctions, which may enhance barrier permeability and contribute to neuroinflammation.*
