Publications by authors named "Sushmita Majumder"
Establishing structure-mechanical property relationships is crucial for understanding and engineering the performance of pharmaceutical molecular crystals. In this study, we employed nanoindentation, a powerful technique that can probe mechanical properties at the nanoscale, to investigate the hardness and elastic modulus of single crystals of succinic acid and L-alanine. Nanoindentation results reveal distinct mechanical behaviors between the two compounds, with L-alanine exhibiting significantly higher hardness and elastic modulus compared to succinic acid.
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- Mechanical properties are crucial in drug formulation and manufacturing, traditionally characterized by large compacts rather than individual particles.
- Modern nanomechanical testing allows for precise measurement of these properties at the single particle level, although it's been underutilized in pharmaceuticals compared to inorganic materials.
- This review highlights nanomechanical techniques' potential in understanding molecular solids' structure-property relationships for better drug development, along with practical pointers for effective sample preparation and testing.