Patient Perception of Prolapse Condition Questionnaire: A Validated Patient-Reported Outcome Measure.

Introduction And Hypothesis: Identifying patient-reported outcome measures allows management of urogenital prolapse to be tailored to reflect symptom bother and expectations of treatment. We devised a new single-item questionnaire, the Patient Perception of Prolapse Condition (PPPC), based on the Patient Perception of Bladder Condition (PPBC). The aim was to evaluate the criterion validity, test/re-test reliability and responsiveness of the PPPC.

Assessment of the impact of urogenital prolapse on sexual dysfunction.

Sexual dysfunction is one of the symptoms that motivates women to seek medical help in the management of urogenital prolapse. Conservative or surgical interventions may be offered to treat the prolapse but the question remains as to whether treatment restores sexual function (SF). This article briefly discusses the assessment of SF in women with a urogenital prolapse and reviews the effect of therapeutic interventions on SF.

Novel targeted bladder drug-delivery systems: a review.

The objective of pharmaceutics is the development of drugs with increased efficacy and reduced side effects. Prolonged exposure of the diseased tissue to the drug is of crucial importance. Drug-delivery systems (DDSs) have been introduced to control rate, time, and place of release.

Digital assessment and quantification of pelvic organ prolapse (DPOP-Q): a randomised cross-over diagnostic agreement trial.

Introduction: Pelvic Organ Prolapse Quantification (POP-Q) system, measured in centimetres using a ruler (e.g. POPstix®), is recommended to quantify prolapse severity.

Patient and surgeon goal achievement 10 years following surgery for pelvic organ prolapse and urinary incontinence.

Introduction And Hypothesis: Assessment of outcomes after pelvic floor surgery remains controversial. The primary aim of our study was to compare patient goal achievement in prolapse/continence surgery with objective/subjective outcomes. The secondary aim was to compare patient goal achievement with overall satisfaction and with that of the surgeon.

Management of prolapse in older women.

Pelvic organ prolapse (POP) is a common problem affecting 37% of women over the age of 80. Review by a specialist with the aid of a validated quality of life questionnaire will help assess bother, as well as the frequency and severity of urinary, bowel and sexual symptoms. Pelvic examination should be carried out to assess the extent of any prolapse and the compartments affected.

Fesoterodine fumarate and the oxybutynin ring for the treatment of urinary incontinence in women.

Introduction: Urinary incontinence (UI) is a prevalent condition among women of all ages. It can have a significant negative impact on women's quality of life causing not only physical but also psychological distress.

Areas Covered: This article aims to provide a review of the pharmacology, efficacy, safety and tolerability of fesoterodine fumarate (the newest anticholinergic launched in the UK) and the oxybutynin vaginal ring (the newest route of drug delivery in development) in the treatment of urgency UI.

Important drug–drug interactions for treatments that target overactive bladder syndrome.

Introduction And Hypothesis: Overactive bladder (OAB) is the term used to describe the symptom complex of urinary urgency,usually accompanied by frequency and nocturia, with or without urgency urinary incontinence, in the absence of urinary tract infection or other obvious pathology. It is a common distressing condition that significantly impairs quality of life(QoL). After lifestyle advice and bladder retraining,antimuscarinic drugs are most commonly used to treat OAB.

Is there a difference between women with or without detrusor overactivity complaining of symptoms of overactive bladder?

Unlabelled: What's known on the subject? and what does the study add?: Overactive bladder syndrome (OAB) is a highly prevalent medical condition, which is linked to the urodynamic observation of detrusor overactivity (DO). Urodynamics detect DO in about half of female patients with OAB. Our study detects significant differences between female patients with OAB with and without DO.

Radiation exposure during videourodynamics in women.

Introduction And Hypothesis: Our aim was to calculate the total radiation exposure and the dose absorbed by specific organs during videourodynamics (VUDS) in women.

Methods: This was a retrospective study of consecutive women attending for VUDS in a tertiary referral urodynamics unit. Tests with missing data and those that were terminated during the filling phase of the cystometry were excluded from the study.

The vagina as a route for drug delivery: a review.

Overactive bladder (OAB) syndrome has a significant deleterious impact on quality of life. After conservative therapy and bladder retaining, antimuscarinic drugs remain the mainstay of OAB management. Oral therapy is associated with frequent side effects, leading to the development of alternative agents and formulations or the use of novel routes of drug administration, such as the vaginal route.

Use of near infrared spectroscopy as an alternative to videourodynamics to detect detrusor overactivity in women with the overactive bladder syndrome.

Objective: To evaluate near infrared spectroscopy as a noninvasive alternative to cystometry for detecting detrusor overactivity in women with overactive bladder (OAB). Although cystometry is considered the "gold standard" investigation for the lower urinary tract, it is invasive. Recently, a noninvasive form of assessment of the lower urinary tract has been introduced using near infrared spectroscopy.

Interstitial cystitis: diagnosis and management.

Interstitial cystitis/painful bladder syndrome is a chronic condition that causes debilitating bladder pain which can be associated with urgency, frequency and nocturia. Its cause is not clear and it is still a disease diagnosed by exclusion. Oral or intravesical therapies are the main stay of treatment whilst surgical procedures are reserved for refractory cases.

Validity and reliability of patient selected goals as an outcome measure in overactive bladder.

Introduction And Hypothesis: The purpose of this study is to assess the validity of patient goal achievement in overactive bladder (OAB).

Methods: Data were taken from a placebo-controlled randomised trial of transdermal oxybutynin and open label extension study. Face validity was assessed using qualitative analysis.

Validity and reliability of the patient's perception of intensity of urgency scale in overactive bladder.

Objective: • To assess the measurement characteristics of the Patient Perception of Intensity of Urgency Scale (PPIUS) in patients with overactive bladder (OAB).

Patients And Methods: • Adult women with at least a 3-month history of OAB. The design was a 4-week, double-blind, randomized, placebo-controlled trial of transdermal oxybutynin, with a 2-week placebo run-in and 8-week, open-label extension.

Ringing the changes in evaluation of urogenital prolapse.

Introduction And Hypothesis: Some women with pelvic organ prolapse (POP) have occult urodynamic stress incontinence (OUSI) and might develop incontinence after POP surgery. Our aim was to determine predictive value of ring pessary test during urodynamics in identifying patients with OUSI, likely to develop stress urinary incontinence (SUI) postoperatively.

Methods: Women with POP were recruited from surgical lists.

Patient-selected goals in overactive bladder: a placebo controlled randomized double-blind trial of transdermal oxybutynin for the treatment of urgency and urge incontinence.

Objective: To assess patient selected goal improvement with transdermal oxybutynin, in a representative population of adult women with overactive bladder (OAB).

Subjects And Methods: Adult women with ≥ 3 month history of OAB symptoms, with or without urgency urinary incontinence, were recruited from a tertiary referral urogynaecology unit. Participants were allocated to either transdermal oxybutynin 3.

Can sex survive pelvic floor surgery?

Introduction/hypothesis: Sexual function in women with pelvic organ prolapse (POP) and stress urinary incontinence (SUI) is adversely affected, but data reporting sexual function following surgery are limited. We aimed to determine effect of pelvic reconstructive surgery on sexual function and to evaluate effect of additional continence procedures.

Methods: Women with POP or SUI were assessed using pelvic organ prolapse quantification (POP-Q) or videocystourethrography.

Validation of the Patient Global Impression of Improvement (PGI-I) for urogenital prolapse.

Introduction And Hypothesis: Currently, there is no global outcome assessment index in prolapse research. Patient Global Impression of Improvement (PGI-I) has only been validated in incontinence. Our aim was to validate its use following prolapse surgery.

Do women with overactive bladder have realistic expectations for therapy?

Introduction And Hypothesis: This study aims to determine what women with overactive bladder (OAB) perceive as 'cure', assesses treatment acceptability and adverse events. It also determines impact on quality of life (QoL) and correlates it with expectations from therapy.

Methods: In 153 women with predominant OAB symptoms, QoL and expectations regarding 'cure' were assessed using KHQ and a novel questionnaire.

Qualifying a quantitative approach to women's expectations of continence surgery.

Introduction And Hypothesis: The objective of this study is to explore expectations and goals of women undergoing continence surgery using a combined quantitative and qualitative approach.

Methods: Women with urinary incontinence, recruited from the waiting list, were assessed with a structured clinical interview, and these data were transcribed and analysed thematically (grounded theory). The Kings Health Questionnaire (KHQ) was used to determine incontinence impact on patient's life.

Quality control in urodynamics: Analysis of an international multi-center study.

Aims: To review the quality of urodynamic traces collected as part of a multi-center Phase II drug trial of a medication for overactive bladder (OAB), in order to assess adherence to the Good Urodynamic Practice (GUP) guidelines. To assess inter-rater reliability (IRR) for the numerical cystometrogram variables, and for the diagnosis of detrusor overactivity (DO).

Methods: Two central reviewers assessed 50 cystometrograms, recording the presence or absence of DO and assessing compliance with GUP guidelines.

Is there a discrepancy between patient and physician quality of life assessment?

Aims: Quality of Life (QoL) assessment remains integral in the investigation of women with lower urinary tract dysfunction. Previous work suggests that physicians tend to underestimate patients' symptoms and the bother that they cause. The aim of this study was to assess the relationship between physician and patient assessed QoL using the Kings Health Questionnaire (KHQ).

Predicting detrusor overactivity using a physician-based scoring system.

Women with lower urinary tract symptoms (LUTS) commonly present to primary care. Management is often based on a symptomatic diagnosis alone although LUTS correlate with urodynamic diagnosis in 65% of cases. The aim of this study was to develop a scoring system to discriminate between the symptoms of stress urinary incontinence (SUI) and overactive bladder (OAB).