Publications by authors named "Sushma Pavuluri"
Article Synopsis
- Triple negative breast cancer (TNBC) is difficult to treat due to the absence of key hormone receptors and HER2, but new targeted therapies, like olaparib for BRCA mutations and immune checkpoint inhibitors, have emerged since 2017.
- A 45-year-old woman diagnosed with BRCA1 mutated TNBC and ovarian cancer faced progression after various treatments, including olaparib and capecitabine, before switching care.
- Her dual metastatic cancers were successfully managed through a combination of gemcitabine, carboplatin, and pembrolizumab, leading to resolution of brain lesions and continued treatment with other medications until December 2023, showcasing a potential new approach for using immunotherapy after PARP inhibitors.
Background: The incidence of breast cancer increases with age. Individuals living in higher socioeconomic communities also have higher incidence secondary to early detection of breast cancer from increased accessibility to mammograms. This retrospective study studied the percentage of new breast cancer cases in the elderly between 2010 and 2019, and investigated the compliance of screening mammography in some of the medically underserved suburbs of southern Chicago.
View Article and Find Full Text PDFThis is a case report of a 63-year-old African American female with a past medical history most significant for metastatic cholangiocarcinoma that presented for evaluation of persistent shortness of breath. Initial workup was remarkable for refractory anemia, moderate schistocytes on peripheral smear and lab work suggestive of a hemolytic anemia. Due to concern for thrombotic thrombocytopenic purpura (TTP), she subsequently underwent several rounds of plasma exchange without significant improvement.
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