Publications by authors named "Sushma P Shenoy"
Background: The Indian traditional medicinal system, Ayurveda, describes several lifestyle practices, processes and medicines as an intervention to treat asthma. Rasayana therapy is one of them and although these treatment modules show improvement in bronchial asthma, their mechanism of action, particularly the effect on DNA methylation, is largely understudied.
Objectives: Our study aimed at identifying the contribution of DNA methylation changes in modulating bronchial asthma phenotype upon Ayurveda intervention.
Article Synopsis
- - Familial dilated cardiomyopathy (DCM) is a common inherited heart condition, and researchers created two stem cell lines from patients with different mutations in the PLN gene associated with DCM.
- - The induced pluripotent stem cells (iPSCs) maintained normal appearance, proper chromosome structure, and the ability to express key pluripotency markers while differentiating into all three germ layers.
- - These patient-specific iPSC lines are important tools for studying the disease mechanisms of DCM linked to PLN mutations in a laboratory setting.
Article Synopsis
- The PLN R14del mutation is linked to arrhythmogenic right ventricular dysplasia (ARVD/C), a heart condition causing arrhythmias and abnormalities in the right ventricle.
- This mutation results from a deletion of three nucleotides (AGA), leading to the loss of the amino acid arginine at position 14, which negatively impacts calcium release regulation.
- The study introduces two induced pluripotent stem cell (iPSC) lines with this mutation, demonstrating normal characteristics and the potential for investigating the disease’s mechanisms.
Article Synopsis
- Hypertrophic cardiomyopathy (HCM) is a genetic heart condition that leads to thickening of the heart muscle, increasing the chances of serious issues like arrhythmias and sudden cardiac death.
- Researchers created two human-induced pluripotent stem cell (iPSC) lines from HCM patients, each with a mutation in key genes (MYBPC3 and PRKAG2).
- These iPSC lines show typical pluripotent characteristics and can differentiate into various cell types, which could help in studying HCM and its underlying causes in a lab setting.
Hypertrophic cardiomyopathy (HCM) is an inherited heart disease that can cause sudden cardiac death and heart failure. HCM often arises from mutations in sarcomeric genes, among which the MYBPC3 is the most frequently mutated. Here we generated two human induced pluripotent stem cell (iPSC) lines from a HCM patient who has a familial history of HCM and his daughter who carries the pathogenic non-coding mutation.
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