Publications by authors named "Sushma J"
Inherited retinal diseases, which results from mutations in over 260 identified genes, affect more than 2 million people globally. The diseases mostly cause severe vision loss in young working population and have severe impact on social economic status of the population. Advances in retinal imaging techniques along with developments in gene identification and cell biology techniques have yielded to a better understanding of the genetic and biochemical mechanisms causing these diseases.
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- The study aims to identify risk factors that lead to unfavorable treatment outcomes for tuberculosis (TB) patients in India, in order to create a better care model for at-risk individuals.
- Conducted as part of a USAID-THALI project in Karnataka and Telangana, the research involved Community Health Workers assessing TB patients for potential risks and following their treatment outcomes.
- Results showed that patients with one or more risk factors—such as being male, having low education, being underweight, having HIV, and previous treatment history—were significantly more likely to experience death or unfavorable outcomes compared to those with no risks.
Light microscopic study of hippocampal sub-regions demonstrated significant number of degenerated nerve cell bodies in the CA3, CA4 and dentate gyrus(Dg) areas of sodium fluoride administered adult female mice. Ultrastructural studies revealed neurodegenrative characteristics like involution of cell membranes, swelling of mitochondria, clumping of chromatin material etc, can be observed in cell bodies of CA3, CA4 and dentate gyrus (Dg). Fluoride intoxicated animals also performed poorly in motor co-ordination tests and maze tests.
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