Photochemical Synthesis of 7,12-Dioxa[8]helicene and Density Functional Theory Studies: Unravelling the One-Way Valve System Involving Steric Crowding and Aromatic Stability.

symmetric chiral 7,12-dioxa[8]helicenes were synthesized through a series of photochemical - isomerization, electrocyclic reaction, and oxidation steps in a stepwise sequential manner at both the ends of 2,9-di(()-styryl)naphtho[2,1-b:7,8-b']difuran. The chemical transformations complemented with density functional theory (DFT) studies delineate some fundamental concepts, exhibiting counter current effects, namely, destabilization caused by increasing steric crowding and stabilization caused by aromatic units on the overall transformation. The calculated energy profile diagram unravels the formation of photoinduced intermediate species with increasing free energies for the - isomerization and the electrocyclic reactions; the reverse processes for the said steps are prevented by a specific barrier-less oxidation step forming aromatic rings, presenting a one-way valve situation.

Directional Approach to Enantiomerically Enriched Functionalized [7]Oxa-helicenoids and Groove-Based Selective Cyanide Sensing.

Several regioselective functionalized mono- and disubstituted [7]oxa-helicenoids have been synthesized in the enantiomerically enriched (90-99% ee) form. These functionalized helicenoids exhibited pronounced spectral and chiroptical properties suitable for sensing applications. In particular, corresponding helicenoid's mono and dialdehydes have been effectively used as chemodosimeters for selective detection of cyanide anions over other anions, while simple aromatic aldehydes do not function as cyanide sensors.