Enhancing Inactivated Yellow Fever 17D Vaccine-Induced Immune Responses in Balb/C Mice Using Alum/CpG.

There are some concerns about the safety of live attenuated yellow fever vaccines (YF-live), particularly viscerotropic adverse events, which have a high mortality rate. The cellular production of the vaccine will not cause these adverse effects and has the potential to extend applicability to those who have allergic reactions, immunosuppression, and age. In this study, inactivated yellow fever (YF) was prepared and adsorbed with Alum/CpG.

Positive intervention of insoluble dietary fiber from defatted rice bran on hyperlipidemia in high fat diet fed rats.

Increasing dietary fiber intake is considered to be an effective way to prevent and relieve the diseases associated with high-income lifestyles. Compared with soluble dietary fiber, comprehensive evaluation about the effects of insoluble dietary fiber on hyperlipidemia is rarely studied. In the present study, the insoluble dietary fiber was extracted from defatted rice bran by enzymatic treatments (IDF-dRB), followed by investigation about the adsorption and antioxidant activities in vitro.

New Diterpenoids and Isocoumarin Derivatives from the Mangrove-Derived Fungus sp.

Two new diterpenoids, hypoxyterpoids A () and B (), and four new isocoumarin derivatives, hypoxymarins A-D (-), together, with seven known metabolites ( and -) were obtained from the crude extract of the mangrove-derived fungus sp. The structures of the new compounds were elucidated on the basis of 1- and 2-dimensional (1D/2D) nuclear magnetic resonance (NMR) spectroscopic and mass spectrometric analysis. The absolute configurations of compounds , , , and were determined by comparison of experimental and calculated electronic circular dichroism (ECD) spectra, and the absolute configurations of C-4' in and C-9 in were determined by [Rh(OCOCF)]-induced ECD spectra.

Peniterpenoids A-C, new sesquiterpenoid metabolites from a wheat cyst nematode Penicillium janthinellum.

Three new sesquiterpenoids, peniterpenoids A - C (1-3), together with six known metabolites (4-9) were isolated from an entomogenous fungus Penicillium janthinellum (LB1.20090001) collected from a wheat cyst nematode. The structures of the new compounds were elucidated based on NMR and HRESIMS spectroscopic analyses.