Publications by authors named "Sushanta Bhattacharya"
Recent Updates on Indole Derivatives as Kinase Inhibitors in the Treatment of Cancer.
Anticancer Agents Med Chem
March 2023
Article Synopsis
- Cancer treatment poses significant challenges globally, prompting the need for new anticancer agents.
- Kinases are being investigated as promising drug targets, with indole derivatives showing effectiveness in inhibiting multiple kinases linked to cancer cell proliferation.
- Recent research highlights specific substitutions on the indole ring that enhance kinase inhibition, with a focus on structure-activity relationship (SAR) studies for developing potential inhibitors.
Tuberculosis is a disease caused by Mycobacterium tuberculosis (Mtb), affecting millions of people worldwide. The emergence of drug resistance is a major problem in the successful treatment of tuberculosis. Due to the commencement of MDR-TB (multi-drug resistance) and XDR-TB (extensively drug resistance), there is a crucial need for the development of novel anti-tubercular agents with improved characteristics such as low toxicity, enhanced inhibitory activity and short duration of treatment.
View Article and Find Full Text PDFSchizophrenia is a chronic neuropsychiatric disorder that affects nearly 1% of the global population. There are various anti-psychotic drugs available for the treatment of schizophrenia, but they have certain side effects; therefore, there is a need to explore and develop novel potential lead compounds against schizophrenia. The currently available drugs e.
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- Diabetes mellitus is a growing global health issue, with significant prevalence rates in developed countries like the USA, China, and India, highlighting a need for new treatments as the number of diabetic patients continues to rise.
- The sodium-glucose co-transporter 2 (SGLT2) has emerged as a key target for Type 2 diabetes treatment, due to its unique mechanism of action that doesn’t involve insulin signaling.
- Various SGLT2 inhibitors, including dapagliflozin and its analogues, are currently being explored in clinical trials, with ongoing research focused on their chemical structures and effectiveness in managing diabetes.
Fungal infections of the central nervous system in three apparently immunocompetent patients are being reported. Two cases of cerebral aspergillosis presenting as intracranial granulomas such as rhinocerebral and intracranial forms, and one of cryptococcal meningitis could be successfully diagnosed by newer diagnostic modality such as antigen detection techniques. The case with cryptococcal infection had typical neuroimaging feature which helped to suspect the underlying diagnosis.
View Article and Find Full Text PDFThe study was conducted to determine the prevalence of neurological diseases in a rural community in Eastern India through a community based survey with the help of trained doctors following on WHO protocol (1981) translated in local vernacular, among 20842 rural residents (male-11037, female-9805, census India-1991, the State of West Bengal in Eastern India) over a period of one yearfrom May 1992 to April 1993 in two phases. Professionals screened the patients by house to house survey in the first phase and later on they were examined in details in temporary clinics in second phase. A total of 606 patients were identified and classified according to well-defined diagnostic criteria.
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