Publications by authors named "Susha K Subash"
Spermatogonial stem cells: A story of self-renewal and differentiation.
Front Biosci (Landmark Ed)
January 2021
Article Synopsis
- Mammalian spermatogenesis involves the development of spermatogonial stem cells (SSC) in the testis into spermatozoa, requiring a balance between self-renewal and differentiation.
- Research shows that both internal cell signals and external signals from the SSC niche influence whether these stem cells self-renew or differentiate.
- The review discusses recent advances in understanding these processes in mice and explores potential clinical applications, such as treating male infertility and gene editing through the manipulation of spermatogonial stem cells.