Diastereoselective synthesis of novel spiro indanone fused pyrano[3,2-]chromene derivatives following hetero-Diels-Alder reaction and anticancer studies.

The development of concise methods for the synthesis of small functionalised spirocyclic molecules is important in the search of new bioactive molecules. To contribute this, here we represent a diastereoselective oxa-hetero-Diels-Alder reaction for the synthesis of novel spiro indanone fused pyrano[3,2-]chromene derivatives and studied their anticancer activities. Using previously less explored cyclic ketone indane-1,3-dione and 3-vinyl-2-chromene derivatives, we obtained novel spiro-heterocyclic frameworks at the interphase between "drug-like" molecules and natural products.