Deep integration of low-cost liquid handling robots in an industrial pharmaceutical development environment.

The pharmaceutical industry is increasingly embracing laboratory automation to enhance experimental efficiency and operational resilience, particularly through the integration of automated liquid handlers (ALHs). This paper explores the integration of the low-cost Opentrons OT-2 liquid handling robot with F. Hoffmann-La Roche AG's in-house workflow orchestration software, AutoLab, to overcome barriers to lab automation.

Cellular Expression and Functional Roles of All 26 Neurotransmitter GPCRs in the Egg-Laying Circuit.

Maps of the synapses made and neurotransmitters released by all neurons in model systems, such as have left still unresolved how neural circuits integrate and respond to neurotransmitter signals. Using the egg-laying circuit of as a model, we mapped which cells express each of the 26 neurotransmitter GPCRs of this organism and also genetically analyzed the functions of all 26 GPCRs. We found that individual neurons express many distinct receptors, epithelial cells often express neurotransmitter receptors, and receptors are often positioned to receive extrasynaptic signals.